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Tetrahydrocannabinol inhibition of macrophage nitric oxide production.
TLDR
Delta 9-Tetrahydrocannabinol (THC) inhibited nitric oxide (NO) production by mouse peritoneal macrophages activated by bacterial endotoxin lipopolysaccharide and interferon-gamma (IFN)-gamma, indicating functional cannabinoid receptors. Expand
Constitutive activity of histamine h(3) receptors stably expressed in SK-N-MC cells: display of agonism and inverse agonism by H(3) antagonists.
TLDR
Receptor affinity was reduced slightly for most impentamine analogs, but the functional activity of the ligands varied from agonist to neutral antagonist and inverse agonist, indicating that subtle changes in the chemical structures of impentamines analogs have major impact on the (de)activation steps of the H(3) receptor. Expand
Molecular basis of the Dark Agouti rat drug oxidation polymorphism: importance of CYP2D1 and CYP2D2.
TLDR
Results suggest that reduced debrisoquine 4-hydroxylase activity in the Dark Agouti rat is caused by the low level expression not only of CYP2D1, but also of CYp2D2. Expand
Negative correlation between plasma thyroid hormone levels and chlorinated hydrocarbon levels accumulated in seals from the coast of Hokkaido, Japan.
TLDR
Findings indicated that the plasma T3 deficiency could be associated with some CHC exposure in larga and ribbon seals and that the responses of plasma thyroid hormones may be useful biomarkers for CHCposure in free-ranging pinnipeds. Expand
Effects of prenatal aflatoxin B1 exposure on behaviors of rat offspring.
TLDR
The results indicate that prenatal exposure to AFB produced a delay of early response development, impaired locomotor coordination, and impaired learning ability in the offspring of rats exposed to AFB during middle pregnancy, and the early gestational exposure appears to produce more effects than latter exposure. Expand
1-Arylnaphthalene lignan: a novel scaffold for type 5 phosphodiesterase inhibitor.
TLDR
It is noteworthy that 27q has the best selectivities against PDE isoforms among PDE5 inhibitors so far reported and was selected for further biological evaluation. Expand
Antitumor activity of tumor necrosis factor-alpha conjugated with polyvinylpyrrolidone on solid tumors in mice.
TLDR
It is suggested that PVP is a useful polymeric modifier for bioconjugation of TNF-alpha to increase its antitumor potency, and multifunctionallyBioconjugated T NF-alpha may be a potentiated antitumors agent for clinical use. Expand
Inhibitory effects of spinorphin, a novel endogenous regulator, on chemotaxis, O2- generation, and exocytosis by N-formylmethionyl-leucyl-phenylalanine (FMLP)-stimulated neutrophils.
TLDR
Spinorphin may be a new endogenous inflammation-regulatory peptide that modulates the interaction of FMLP with its receptor and causes a decrease of the FMLP-induced intracellular calcium concentration [Ca2+], which acts as a second messenger leading to PMN functions. Expand
Modeling of human thromboxane A2 receptor and analysis of the receptor-ligand interaction.
TLDR
A model for the human TXA2 receptor, a member of the G protein-coupled receptor family with seven transmembrane segments, was constructed on the basis of its amino acid sequence, which was determined recently. Expand
Inhibition of angiogenesis by humulone, a bitter acid from beer hop.
TLDR
Humulone is a potentAngiogenic inhibitor, and may be a novel powerful tool for the therapy of various angiogenic diseases involving solid tumor growth and metastasis. Expand
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