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Interferon gamma (IFN-γ) disrupts energy expenditure and metabolic homeostasis by suppressing SIRT1 transcription
TLDR
The data delineate an IFN-γ/HIC1/CIITA axis that contributes to metabolic dysfunction by suppressing SIRT1 transcription in skeletal muscle cells and shed new light on the development of novel therapeutic strategies against type 2 diabetes. Expand
RelB enhances prostate cancer growth: implications for the role of the nuclear factor-kappaB alternative pathway in tumorigenicity.
TLDR
Results reveal a tumor-supportive role of RelB, implicate the NF-kappaB alternative pathway as a potential target for preventing prostate cancer, and suggest the use of IL-8 as a marker for prostate cancer prognosis. Expand
The role of oxidative stress in the biological responses of lung epithelial cells to cigarette smoke
TLDR
Intervention studies using antioxidants have provided compelling evidence that oxidative stress plays a critical role in the aetiology of smoking-related disorders. Expand
Suppression of RelB-mediated manganese superoxide dismutase expression reveals a primary mechanism for radiosensitization effect of 1α,25-dihydroxyvitamin D3 in prostate cancer cells
TLDR
Results suggest that suppression of manganese superoxide dismutase is a mechanism by which 1α,25-(OH)2D3 exerts its radiosensitization effect and that 1 α,25-dihydroxyvitamin D3 may serve as an effective pharmacologic agent for selectively sensitizing prostate cancer cells to IR via suppression of antioxidant responses in mitochondria. Expand
Mutations in the SOD2 Promoter Reveal a Molecular Basis for an Activating Protein 2-Dependent Dysregulation of Manganese Superoxide Dismutase Expression in Cancer Cells
TLDR
The results suggest that the high level of MnSOD observed in aggressive cancer cells may be due, in part, to the absence of AP-2 transcriptional repression. Expand
p53 is an important factor for the radiosensitization effect of 2-deoxy-D-glucose.
TLDR
It is demonstrated that the improvement of radiotherapy by 2-deoxy-D-glucose (2DG) is p53-dependent and inhibition of glycolysis may only be beneficial for radiation therapy of cancer expressing wild-type p53. Expand
Glutamate mediates the function of melanocortin receptor 4 on Sim1 neurons in body weight regulation.
TLDR
Glutamate is established as the primary neurotransmitter that mediates MC4Rs on Sim1 neurons in body weight regulation and dramatically reduced obesity in Mc4r-null mice. Expand
SN52, a novel nuclear factor-κB inhibitor, blocks nuclear import of RelB:p52 dimer and sensitizes prostate cancer cells to ionizing radiation
TLDR
It is shown that ionizing radiation (IR) enhances nuclear import of RelB, leading to up-regulation of its target gene, manganese superoxide dismutase (MnSOD), and renders prostate cancer cells resistant to IR. Expand
Megakaryocytic Leukemia 1 Bridges Epigenetic Activation of NADPH Oxidase in Macrophages to Cardiac Ischemia-Reperfusion Injury
TLDR
The data delineate an MKL1-MOF-NOX axis in macrophages that contributes to IR injury, and as such the data have provided novel therapeutic targets in the treatment of ischemic heart disease. Expand
The Role of a Single-stranded Nucleotide Loop in Transcriptional Regulation of the Human sod2 Gene*
TLDR
It is shown that nucleophosmin (NPM), a RNA-binding protein, binds to an 11G single-stranded loop in the promoter region and serves to integrate the Sp1 and NF-κB responses and suggest a novel molecular mechanism for communication between the enhancer and the GC-rich promoter. Expand
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