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Toll-like receptor 4 is a sensor for autophagy associated with innate immunity.
Autophagy has recently been shown to be an important component of the innate immune response. The signaling pathways leading to activation of autophagy in innate immunity are not known. Here weExpand
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Novel as1 and as2 defects in leaf adaxial-abaxial polarity reveal the requirement for ASYMMETRIC LEAVES1 and 2 and ERECTA functions in specifying leaf adaxial identity
The shoot apical meristem (SAM) of seed plants is the site at which lateral organs are formed. Once organ primordia initiate from the SAM, they establish polarity along the adaxial-abaxial,Expand
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A “dock, lock, and latch” Structural Model for a Staphylococcal Adhesin Binding to Fibrinogen
Gram-positive pathogens such as staphylococci contain multiple cell wall-anchored proteins that serve as an interface between the microbe and its environment. Some of these proteins act as adhesinsExpand
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Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding
We report epidemiological and clinical investigations on ten pediatric SARS-CoV-2 infection cases confirmed by real-time reverse transcription PCR assay of SARS-CoV-2 RNA. Symptoms in these casesExpand
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  • Open Access
Loss of Inhibitory Interneurons in the Dorsal Spinal Cord and Elevated Itch in Bhlhb5 Mutant Mice
Itch is the least well understood of all the somatic senses, and the neural circuits that underlie this sensation are poorly defined. Here we show that the atonal-related transcription factor Bhlhb5Expand
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A ‘Collagen Hug’ Model for Staphylococcus aureus CNA binding to collagen
The structural basis for the association of eukaryotic and prokaryotic protein receptors and their triple‐helical collagen ligand remains poorly understood. Here, we present the crystal structures ofExpand
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Lbx1 and Tlx3 are opposing switches in determining GABAergic versus glutamatergic transmitter phenotypes
Most neurons in vertebrates make a developmental choice between two principal neurotransmitter phenotypes (glutamatergic versus GABAergic). Here we show that the homeobox gene Lbx1 determines aExpand
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Toxicity of nano- and micro-sized ZnO particles in human lung epithelial cells
This is the first comprehensive study to evaluate the cytotoxicity, biochemical mechanisms of toxicity, and oxidative DNA damage caused by exposing human bronchoalveolar carcinoma-derived cellsExpand
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Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle priming
Munc18-1 and soluble NSF attachment protein receptors (SNAREs) are critical for synaptic vesicle fusion. Munc18-1 binds to the SNARE syntaxin-1 folded into a closed conformation and to SNAREExpand
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Increased Expression of Mitotic Checkpoint Genes in Breast Cancer Cells with Chromosomal Instability
Purpose: Most breast cancers have chromosomal instability that seems related to defective mitotic spindle checkpoints. Because the molecular basis of this defect is unknown, we evaluated breastExpand
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