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Salmonella pathogenicity island 2-dependent evasion of the phagocyte NADPH oxidase.
A type III protein secretion system encoded by Salmonella pathogenicity island 2 (SPI2) has been found to be required for virulence and survival within macrophages. Here, SPI2 was shown to allowExpand
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Regional Mu Opioid Receptor Regulation of Sensory and Affective Dimensions of Pain
The endogenous opioid system is involved in stress responses, in the regulation of the experience of pain, and in the action of analgesic opiate drugs. We examined the function of the opioid systemExpand
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Phytochromes: photosensory perception and signal transduction
The phytochrome family of photoreceptors monitors the light environment and dictates patterns of gene expression that enable the plant to optimize growth and development in accordance with prevailingExpand
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Phytochromes: photosensory perception and signal transduction.
The phytochrome family of photoreceptors monitors the light environment and dictates patterns of gene expression that enable the plant to optimize growth and development in accordance with prevailingExpand
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Control of a Mucosal Challenge and Prevention of AIDS by a Multiprotein DNA/MVA Vaccine
Heterologous prime/boost regimens have the potential for raising high levels of immune responses. Here we report that DNA priming followed by a recombinant modified vaccinia Ankara (rMVA) boosterExpand
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Total Synthesis of a Functional Designer Eukaryotic Chromosome
Designer Chromosome One of the ultimate aims of synthetic biology is to build designer organisms from the ground up. Rapid advances in DNA synthesis has allowed the assembly of complete bacterialExpand
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Lysophosphatidylcholine as a Ligand for the Immunoregulatory Receptor G2A
Although the biological actions of the cell membrane and serum lipid lysophosphatidylcholine (LPC) in atherosclerosis and systemic autoimmune disease are well recognized, LPC has not been linked to aExpand
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HPV and Therapeutic Vaccines: Where are We in 2010?
The discovery of human papillomavirus (HPV) as a necessary etiological factor for cervical cancer has spurred the development of preventive and therapeutic HPV vaccines for the control ofExpand
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TLR9 ligation in pancreatic stellate cells promotes tumorigenesis
Zambirinis et al. show that TLR9 stimulation has a protumorigenic effect in pancreatic carcinoma by inducing pancreatic stellate cells to become fibrogenic and produce chemokines that stimulateExpand
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LAH4 enhances CD8+ T cell immunity of protein/peptide-based vaccines.
It is now clear that CD8+ T cells are crucial for therapeutic immunity against chronic viral infections and/or tumors. We reason that a strategy capable of improving CD8+ T cell activation wouldExpand
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