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Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2
TLDR
It is reported that Ror2 also positively modulates Wnt3a-activated canonical signaling in a lung carcinoma, H441 cell line and these findings support a functional scheme whereby regulation of Wnt signaling is achieved by cooperative functions of multiple mediators.
Epithelium-specific deletion of TGF-β receptor type II protects mice from bleomycin-induced pulmonary fibrosis.
TLDR
These findings are the first to demonstrate a specific role for TGF-β signaling in the lung epithelium in the pathogenesis of pulmonary fibrosis.
Progenitors of Secondary Crest Myofibroblasts Are Developmentally Committed in Early Lung Mesoderm
TLDR
The Gli1‐creERT2 mouse line represents a novel tool in the analysis of mesenchymal cell biology and alveolar formation during lung development and identified the progenitors of secondary crest myofibroblasts, a hitherto intractable cell type that plays a key role in alveolars formation, a vital process about which little is currently known.
Signaling via Alk5 controls the ontogeny of lung Clara cells
TLDR
Using lung epithelial cells, it is shown that Alk5-regulated Hes1 expression is stimulated through Pten and the MEK/ERK and PI3K/AKT pathways, which indicates that the signaling pathway by which TGFβ/ALK5 regulates Clara cell differentiation may entail inhibition of Pten expression, which in turn activates ERK and AKT phosphorylation.
The major podocyte protein nephrin is transcriptionally activated by the Wilms' tumor suppressor WT1.
TLDR
Nphrin is identified as a direct transcriptional target for Wt1 and underline the importance of WT1 as a key regulator in podocyte function.
Physical and Functional Interactions between Homeodomain NKX2.1 and Winged Helix/Forkhead FOXA1 in Lung Epithelial Cells
TLDR
The results show that NKX2.1 interacts physically and functionally with FOXA1, and suggest a novel mode of selective gene regulation by proximo-distal gradient distribution of and functional interactions between forkhead and homeodomain transcription factors.
Ligand‐independent transforming growth factor‐β type I receptor signalling mediates type I collagen‐induced epithelial–mesenchymal transition
TLDR
The notion that alveolar epithelial cell (AECs) can acquire a mesenchymal phenotype following injury in vivo is supported and type I collagen is implicate as a key regulator of EMT in AECs through signalling via Alk5, likely in a TGFβ ligand‐independent manner.
Deletion of Pten expands lung epithelial progenitor pools and confers resistance to airway injury.
TLDR
Pten has a pivotal role in lung stem cell homeostasis, cell differentiation, and consequently resistance to lung injury and conferred an overall selective advantage to naphthalene injury compared with wild-type control mice.
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