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Quantitative Proteomics Reveals the Function of Unconventional Ubiquitin Chains in Proteasomal Degradation
All seven lysine residues in ubiquitin contribute to the synthesis of polyubiquitin chains on protein substrates. Whereas K48-linked chains are well established as mediators of proteasomalExpand
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Mitigating SAT Attack on Logic Locking
We show that the number of SAT attack iterations to reveal the correct key in a circuit comprising an Anti-SAT block is an exponential function of the key-size thereby making the SAT attack computationally infeasible. Expand
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Poly-dipeptides encoded by the C9orf72 repeats bind nucleoli, impede RNA biogenesis, and kill cells
Dipeptide repeat peptides on the attack Certain neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), are associated with expanded dipeptides translated from RNA transcripts ofExpand
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ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner
R-spondin proteins strongly potentiate Wnt signalling and function as stem-cell growth factors. Despite the biological and therapeutic significance, the molecular mechanism of R-spondin actionExpand
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Cell-free Formation of RNA Granules: Bound RNAs Identify Features and Components of Cellular Assemblies
Cellular granules lacking boundary membranes harbor RNAs and their associated proteins and play diverse roles controlling the timing and location of protein synthesis. Formation of such granules wasExpand
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Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling.
Aldehyde dehydrogenase (ALDH) is a candidate marker for lung cancer cells with stem cell-like properties. Immunohistochemical staining of a large panel of primary non-small cell lung cancer (NSCLC)Expand
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The Yeast Hex3·Slx8 Heterodimer Is a Ubiquitin Ligase Stimulated by Substrate Sumoylation*
Hex3 and Slx8 are Saccharomyces cerevisiae proteins with important functions in DNA damage control and maintenance of genomic stability. Both proteins have RING domains at their C termini. SuchExpand
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NRF2 regulates serine biosynthesis in non-small cell lung cancer
Tumors have high energetic and anabolic needs for rapid cell growth and proliferation, and the serine biosynthetic pathway was recently identified as an important source of metabolic intermediatesExpand
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Neural Trojans
We propose the neural Trojan attack which is carried out by the trainer of the neural IP. Expand
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The starvation hormone, fibroblast growth factor-21, extends lifespan in mice
Fibroblast growth factor-21 (FGF21) is a hormone secreted by the liver during fasting that elicits diverse aspects of the adaptive starvation response. Among its effects, FGF21 induces hepatic fattyExpand
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