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Naive tumor-specific CD4+ T cells differentiated in vivo eradicate established melanoma
In vitro differentiated CD8+ T cells have been the primary focus of immunotherapy of cancer with little focus on CD4+ T cells. Immunotherapy involving in vitro differentiated T cells given afterExpand
Transport of nerve growth factor encapsulated into liposomes across the blood-brain barrier: in vitro and in vivo studies.
  • Y. Xie, Liya Ye, +4 authors Xin-pu Hou
  • Biology, Medicine
  • Journal of controlled release : official journal…
  • 20 June 2005
A nerve growth factor (NGF) was encapsulated into liposomes in order to protect it from the enzyme degradation in vivo and promote it permeability across the blood-brain barrier (BBB). RMP-7, aExpand
Nitrogen-doped graphene with high nitrogen level via a one-step hydrothermal reaction of graphene oxide with urea for superior capacitive energy storage
Nitrogen-doped graphene nanosheets (NGS) with the nitrogen level as high as 10.13 atom% were synthesized via a simple hydrothermal reaction of graphene oxide (GO) and urea. N-doping and reduction ofExpand
A deep investigation into the adipogenesis mechanism: Profile of microRNAs regulating adipogenesis by modulating the canonical Wnt/β-catenin signaling pathway
BackgroundMicroRNAs (miRNAs) are a large class of tiny non-coding RNAs (~22-24 nt) that regulate diverse biological processes at the posttranscriptional level by controlling mRNA stability orExpand
Altered miRNA expression in sputum for diagnosis of non-small cell lung cancer.
UNLABELLED Analysis of molecular genetic markers in biological fluids has been proposed as a useful tool for cancer diagnosis. MicroRNAs (miRNAs) are small regulatory RNAs that are frequentlyExpand
RUNX1, a transcription factor mutated in breast cancer, controls the fate of ER-positive mammary luminal cells
RUNX1 encodes a RUNX family transcription factor (TF) and was recently identified as a novel mutated gene in human luminal breast cancers. We found that Runx1 is expressed in all subpopulations ofExpand
[Effects of formaldehyde on germ cells of male mice].
General toxicity and genetic materials damage of formaldehyde on germ cells in different stages was studied. In order to discover the toxicity mechanism of formaldehyde on germ cells and theExpand
Restoring Immune Function of Tumor-Specific CD4+ T Cells during Recurrence of Melanoma
Recurrent solid malignancies are often refractory to standard therapies. Although adoptive T cell transfer may benefit select individuals, the majority of patients succumb to their disease. ToExpand
Protective role of autophagy in AGE-induced early injury of human vascular endothelial cells.
Advanced glycation end-products (AGEs) contribute to the pathogenesis of diabetes mellitus and atherosclerosis by promoting vascular endothelial cell proliferation, migration, damage and death. InExpand
Triptolide ameliorates IL-10-deficient mice colitis by mechanisms involving suppression of IL-6/STAT3 signaling pathway and down-regulation of IL-17.
  • Y. Li, Chao Yu, +4 authors J. Li
  • Biology, Medicine
  • Molecular immunology
  • 30 September 2010
Triptolide is an active component of extracts derived from the medicinal vine Tripterygium Wilfordii Hook. f. (TWHF) whose extracts have been used to treat inflammatory bowel disease (IBD). We haveExpand