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Birth defects in children conceived by in vitro fertilization and intracytoplasmic sperm injection: a meta-analysis.
OBJECTIVE To conduct a meta-analysis of studies assessing the effect of IVF and intracytoplasmic sperm injection (ICSI) on birth defects. DESIGN Meta-analysis. SETTING Centers for reproductive… Expand
Early Second-Trimester Serum MiRNA Profiling Predicts Gestational Diabetes Mellitus
Background Gestational diabetes mellitus (GDM) is one type of diabetes that presents during pregnancy and significantly increases the risk of a number of adverse consequences for the fetus and… Expand
Assessing hormone receptor activities of pyrethroid insecticides and their metabolites in reporter gene assays.
- Guizhen Du, Ouxi Shen, +6 authors X. Wang
- Biology, Medicine
- Toxicological sciences : an official journal of…
- 1 July 2010
Pyrethroid insecticides, the most commonly used insecticides worldwide, are suspected endocrine-disrupting chemicals. But their interactions with hormone receptors are still unclear. The present… Expand
High urinary bisphenol A concentrations in workers and possible laboratory abnormalities
Objectives Bisphenol A (BPA) is widely used in epoxy resins in China. There are few reports on the adverse health effects of occupational exposure to BPA. This study examined associations between… Expand
Perfluorooctane sulfonate (PFOS) affects hormone receptor activity, steroidogenesis, and expression of endocrine-related genes in vitro and in vivo.
- Guizhen Du, Jialei Hu, +6 authors X. Wang
- Biology, Medicine
- Environmental toxicology and chemistry
- 1 February 2013
Perfluorooctane sulfonate (PFOS) is a widespread and persistent chemical in the environment. We investigated the endocrine-disrupting effects of PFOS using a combination of in vitro and in vivo… Expand
A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia
Non-obstructive azoospermia (NOA) is one of the most severe forms of male infertility. Its pathophysiology is largely unknown, and few genetic influences have been defined. To identify common… Expand
Change in circulating microRNA profile of obese children indicates future risk of adult diabetes.
PURPOSE Childhood obesity increases susceptibility to type 2 diabetes (T2D) in adults. Circulating microRNAs (miRNAs) in serum have been proposed as potential diagnostic biomarkers, and they may… Expand
Developmental toxicity of cypermethrin in embryo-larval stages of zebrafish.
Cypermethrin, a type II pyrethroid insecticide, is widely used throughout the world in agriculture, forestry, horticulture and homes. Though the neurotoxicity of cypermethrin has been thoroughly… Expand
The b2/b3 subdeletion shows higher risk of spermatogenic failure and higher frequency of complete AZFc deletion than the gr/gr subdeletion in a Chinese population.
Microdeletions in the azoospermia factor (AZF) regions on the long arm of the human Y chromosome are known to be associated with spermatogenic failure. Although AZFc is recurrently deleted in… Expand
Partial deletions are associated with an increased risk of complete deletion in AZFc: a new insight into the role of partial AZFc deletions in male infertility
Background: The AZFc region on the human Y chromosome has been found to be functionally important in spermatogenesis. Complete AZFc deletion is one of the most frequent causes of male infertility and… Expand