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Immunomodulatory effects of mesenchymal stem cells involved in favoring type 2 T cell subsets.
Cytotoxic Effect of Icaritin and Its Mechanisms in Inducing Apoptosis in Human Burkitt Lymphoma Cell Line
It is demonstrated that icaritin showed cytotoxicity, inhibited cell growth, caused S arrest, and induced apoptosis in Burkitt lymphoma cells and provided a rationale for the further evaluation of icar itin for BurkITT lymphoma therapy.
Synergic effect of 3′-azido-3′-deoxythymidine and arsenic trioxide in suppressing hepatoma cells
- Che Chen, Yingmei Zhang, Yong Wang, Dejun Huang, Y. Xi, Yongmei Qi
- Chemistry, BiologyAnti-cancer drugs
- 1 June 2011
The results showed that the growth inhibitory and apoptotic effects of As2O3 and AZT on human hepatoma cells could be related to the inhibition of telomerase and the activation of caspase 3.
In vivo and in vitro anti-tumour response of selenium-protein polysaccharide extracted from rich selenium Agaricus blazei
SPP extracted from rich selenium A. blazei can inhibit growth of implanted Sarcoma 180 and promote lymphocyte transformation and NK cells activity in vivo and in vitro, and can inhibit proliferation and cause apoptotic morphological changes and the fragmentation of internucleosomal DNA.
[Relationship of MPO and NQO1 gene polymorphisms with susceptibility to acute leukemia].
It is concluded that the MPO and NQO1 gene polymorphisms are associated with susceptibility to AL and the AL risk may decrease in patients carrying MPO (G-463A) mutant gene (GA/AA), while the Al risk may increase in patientscarry NQo1 (C-609T) mutant genes (TC/TT).
[Relation of GSTP1 and CYP2E1 polymorphisms with susceptibility to acute leukemia].
It is concluded that the GSTP 1 gene is related with susceptibility to AML, the AL risk for persons with lle/Val + Val/Val of GSTP1 gene decreased, while CYP2E1 gene is not related to susceptibility to AL, and the AML risk for people in combination of GSTp1 wildtype with CYP1 hybrid and mutant genotype can be further decreased.
Effects of Clostridium difficile toxin A on K562/A02 cell proliferation, apoptosis and multi-drug resistance
- Y. Xi, Zhuan-Zhen Ma, H. Zhang, Maowen Yuan, Lina Wang
- Biology, MedicineOncology letters
- 1 February 2018
It is suggested that TcdA may be able to inhibit K562/A02 cell growth, induce cell apoptosis by decreasing P-gp levels and caspase-3 activation, and partially reverse MDR.
Primary mechanism of apoptosis induction in a leukemia cell line by fraction FA-2-b-ß prepared from the mushroom Agaricus blazei Murill
Fraction FA-2-b-ss can induce HL-60 cell apoptosis and that the combined effect of down- regulation of telomerase activity and up-regulation of mRNA expression of the caspase-3 gene could be the primary mechanism of induction of apoptosis are shown.
Effects of AZT and RNA-protein complex (FA-2-b-beta) extracted from Liang Jin mushroom on apoptosis of gastric cancer cells.
- Yan-qing Sun, T. Guo, Y. Xi, Che Chen, Jin Wang, Ziren Wang
- Biology, ChemistryWorld journal of gastroenterology
- 21 August 2007
Combination of AZT and FA-2-b-beta has an obviously synergetic effect in the gastric cancer cells MKN45, which has provided a new approach to the treatment of gastric cancers clinically.
Icaritin: A Novel Natural Candidate for Hematological Malignancies Therapy
The existing evidence indicates that icaritin is a potential novel therapeutic agent for neoplasms as with hematological malignancies.