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A New Insect-Specific Flavivirus from Northern Australia Suppresses Replication of West Nile Virus and Murray Valley Encephalitis Virus in Co-infected Mosquito Cells
TLDR
It is demonstrated that prior infection of cultured mosquito cells with PCV suppressed subsequent replication of the medically significant West Nile and Murray Valley encephalitis viruses by 10–43 fold, suggesting that superinfection exclusion can occur between ISFs and vertebrate-infecting flaviviruses despite their high level of genetic diversity. Expand
Post-translational regulation and modifications of flavivirus structural proteins.
TLDR
The insights gained from research into post-translational regulation of structural proteins are beginning to be applied in the rational design of improved flavivirus vaccine candidates and make attractive targets for the development of novel therapeutics. Expand
The West Nile Virus-Like Flavivirus Koutango Is Highly Virulent in Mice due to Delayed Viral Clearance and the Induction of a Poor Neutralizing Antibody Response
TLDR
A West Nile-like virus, Koutango virus (WNVKOU), was identified that was more virulent than a known virulent lineage I virus, WNVNY99, and was associated with poor viral clearance and the induction of a poor neutralizing antibody response. Expand
A Kunjin Replicon Virus-like Particle Vaccine Provides Protection Against Ebola Virus Infection in Nonhuman Primates.
TLDR
It is suggested that KUN VLPs encoding GP/D637L represent a viable EBOV vaccine candidate in nonhuman primates. Expand
West Nile virus infection and interferon alpha treatment alter the spectrum and the levels of coding and noncoding host RNAs secreted in extracellular vesicles
TLDR
WNV infection and IFN-alpha treatment alter the spectrum and the levels of mRNAs, miRNAs and sncRNAs in EVs and are associated with viral processes and host response to infection. Expand
A vaccinia-based single vector construct multi-pathogen vaccine protects against both Zika and chikungunya viruses
TLDR
This represents the first single-vector construct, multi-pathogen vaccine encoding large polyproteins, and offers both simplified manufacturing and formulation, and reduced “shot burden” for these often co-circulating arboviruses. Expand
De Novo Generation and Characterization of New Zika Virus Isolate Using Sequence Data from a Microcephaly Case
TLDR
ZIKVNatal thus has no laboratory passage history and is unequivocally associated with CZS, and illustrates a novel methodology for obtaining an authentic functional viral isolate by using data from deep sequencing of infected tissues. Expand
A recombinant platform for flavivirus vaccines and diagnostics using chimeras of a new insect-specific virus
TLDR
A new insect-specific flavivirus, Binjari virus, was found to be remarkably tolerant for exchange of its structural protein genes (prME) with those of the aforementioned pathogenic vertebrate-infecting flaviviruses (VIFs). Expand
Misperceived Risks of Zika-related Microcephaly in India.
TLDR
Spread along with the virus is misinformation that a ZIKV mutation is responsible for microcephaly, and putting too much onus on a single mutation could enhance a crisis in India. Expand
Antigenic Characterization of New Lineage II Insect-Specific Flaviviruses in Australian Mosquitoes and Identification of Host Restriction Factors
TLDR
The data are the first to uncover the mechanisms that restrict the growth of Lin II ISFs in vertebrate cells and provides new insights into the evolution of these viruses and the mechanisms associated with host switching that may allow new mosquito-borne viral diseases to emerge. Expand
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