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Cardiolipin remodeling by ALCAT1 links oxidative stress and mitochondrial dysfunction to obesity.
It is shown that ALCAT1, a lyso-CL acyltransferase upregulated by oxidative stress and diet-induced obesity (DIO), catalyzes the synthesis of CL species that are highly sensitive to oxidative damage, leading to mitochondrial dysfunction, ROS production, and insulin resistance. Expand
CREPT accelerates tumorigenesis by regulating the transcription of cell-cycle-related genes.
A gene CREPT is reported that is preferentially expressed in diverse human tumors and a mechanism where CREPT increases cyclin D1 transcription during tumorigenesis is revealed, through enhancing the recruitment of RNAPII to the promoter region, possibly as well as chromatin looping. Expand
GABARAPL1 Negatively Regulates Wnt/β-catenin Signaling by Mediating Dvl2 Degradation through the Autophagy Pathway
It is suggested that GABARAPL1 as a tumor repressor inhibits Wnt signaling via mediating Dvl2 degradation through the autophagy pathway. Expand
p15RS/RPRD1A (p15INK4b-related Sequence/Regulation of Nuclear Pre-mRNA Domain-containing Protein 1A) Interacts with HDAC2 in Inhibition of the Wnt/β-Catenin Signaling Pathway*
Background: p15RS/RPRD1A inhibits Wnt/β-catenin signaling by recruiting HDAC2. Results: p15RS interacts with HDAC2 and enhances the occupancy of HDAC2 to promoters of Wnt-targeted genes, keepingExpand
RACK1 promotes Bax oligomerization and dissociates the interaction of Bax and Bcl-XL.
Results indicate that RACK1 promotes apoptosis by promoting Bax oligomerization and dissociating the complex of Bax and Bcl-XL. Expand
Caspase 3 is Activated through Caspase 8 instead of Caspase 9 during H2O2-induced Apoptosis in HeLa Cells
The results suggest that, during H H2O2-induced apoptosis, caspase 3 is activated directly through casp enzyme 8 and is not through the mitochondria-dependent caspases 9 activation. Expand
Regulation of Bax activation and apoptotic response to UV irradiation by p53 transcription-dependent and -independent pathways.
Data indicate that the nuclear p53 promotes PUMA expression, which then displaces cytoplasmic p53 from Bcl-x(L), allowing p53 to induce mitochondrial permeabilization, thereby triggering apoptosis. Expand
PUMA promotes Bax translocation by competitive binding to Bcl-Xl during UV-induced apoptosis
Ultraviolet (UV) irradiation can induce apoptosis through both the membrane death receptor and the intrinsic apoptotic signaling pathways as DNA-damaging agents. PUMA, a BH3-only Bcl-2 familyExpand
p15RS Attenuates Wnt/β-Catenin Signaling by Disrupting β-Catenin·TCF4 Interaction*
It is demonstrated that inhibition of Wnt signaling by p15RS leads to decreased expression of CYCLIN D1 and c-MYC, two Wnt targeted genes critical for cell growth. Expand
Bid is not required for Bax translocation during UV-induced apoptosis.
Data suggest that Bax translocation by UV irradiation is a Bid-independent event and inhibited by overexpression of Bcl-x(L), an anti-apoptotic protein. Expand