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Relationship between effects on time-to-disease progression and overall survival in studies of metastatic breast cancer
The relationship between overall survival (OS) and disease progression end points has been demonstrated in colorectal, colon, and non-small cell lung cancers. We assessed the association between OS… Expand
Estrogen receptor beta genetic variants and combined oral contraceptive use as relates to the risk of hypertension in Chinese women.
BACKGROUND AND AIMS Estrogen receptor beta (ESR2) plays an important role in cardiovascular physiology and blood pressure regulation, whereas estrogens may influence gene expression, growth, and… Expand
Impact of lapatinib plus trastuzumab versus single-agent lapatinib on quality of life of patients with trastuzumab-refractory HER2+ metastatic breast cancer.
- Y. Wu, M. Amonkar, +5 authors H. Burstein
- Annals of oncology : official journal of the…
- 1 December 2011
BACKGROUND Progression-free survival (PFS) was significantly longer for the lapatinib plus trastuzumab (L+T) arm than for L alone in a phase III, randomized, open-label study of women with human… Expand
Dyslipidaemia, combined oral contraceptives use and their interaction on the risk of hypertension in Chinese women
The objective of the study was to assess the associations of dyslipidaemia, combined oral contraceptive (COC) use and their interaction on the risk of hypertension in Chinese women. In a case–control… Expand
The Protective Effect of Sonneratia apetala Fruit Extract on Acetaminophen-Induced Liver Injury in Mice
- J. Liu, Dandan Luo, +7 authors Z. Su
- Chemistry, Medicine
- Evidence-based complementary and alternative…
- 19 June 2019
Acute liver injury is a common consequence of taking overdose of acetaminophen (APAP). The aim of this study was to evaluate the antioxidant activity and hepatoprotective effect of a mangrove plant… Expand
Military Simulation Big Data: Background, State of the Art, and Challenges
This paper firstly reviewed several large-scale military simulations producing big data (MS big data) for a variety of usages . Expand
COC use, ACE/AGT gene polymorphisms, and risk of stroke
Objectives To clarify the effects of the association between combined oral contraceptives (COC) use and ACE/AGT gene on stroke risk, and to undertake a preliminarily study of the molecular mechanism… Expand
Impact of different contraceptive methods on quality of life in rural women of the Jiangsu province in China.
BACKGROUND The combined oral contraceptives (COCs) and intrauterine devices (IUDs) are the most common contraceptive methods used by women. Women's choices of contraceptive method are largely… Expand
Lapatinib plus letrozole compared with letrozole alone as first-line therapy in hormone receptor positive HER2+ metastatic breast cancer (MBC): A quality-of-life (QOL) analysis.
- B. Sherif, B. Sherrill, +4 authors S. Johnston
- Journal of clinical oncology : official journal…
- 22 September 2016
1039 Background: A phase III randomized double-blind multicenter trial compared lapatinib plus letrozole (L+Let) with letrozole plus placebo (Let), as first-line therapy for hormone receptor positive… Expand
[Association between low-dose oral contraceptive use and stroke in Chinese women].
OBJECTIVE To investigate the association between low-dose combined oral contraceptive (COC) widely distributed in China and the risk of hemorrhagic stroke so as to decrease the adverse reaction of… Expand