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New cytotoxic withanolides from Physalis peruviana
Investigation of the extracts of Physalis peruviana L. has led to the isolation of seven new withanolides, phyperunolide A (1), phyperunolide B (2), phyperunolide C (3), phyperunolide D (4),Expand
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Isoquinoline alkaloids and lignans from Rollinia mucosa
Romucosine (1), a novel aporphinoid alkaloid possessing a N-(methoxycarbonyl) group, along with 12 known compounds including eight isoquinoline alkaloids, anonaine (2), glaucine, purpureine,Expand
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Sesquiterpenoids from Neolitsea parvigemma: Isolation, oxidation products and antiplatelet actions
Abstract Two novel sesquiterpenoids of the furanogermacrane type, deacetylzeylanine (9) and parvigemonol (10), have been isolated from the stems of Neolitsea parvigemma. The autoxidation of the knownExpand
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Duodenal reflux induces cyclooxygenase-2 in the esophageal mucosa of rats: evidence for involvement of bile acids.
BACKGROUND & AIMS Reflux of duodenal contents including bile acids is believed to contribute to esophageal injury and Barrett's esophagus. Cyclooxygenase (COX)-2, an inducible form of COX, has beenExpand
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Tubocapsenolide A, a Novel Withanolide, Inhibits Proliferation and Induces Apoptosis in MDA-MB-231 Cells by Thiol Oxidation of Heat Shock Proteins*
Tubocapsenolide A (TA), a novel withanolide-type steroid, exhibits potent cytotoxicity against several human cancer cell lines. In the present study, we observed that treatment of human breast cancerExpand
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Multiplexed assay panel of cytotoxicity in HK-2 cells for detection of renal proximal tubule injury potential of compounds.
Proximal tubules of the kidneys are one of the most common targets of nephrotoxic drugs and chemicals. Screens to predict nephrotoxic potential of compounds with insights to mechanisms of toxicityExpand
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Raf/ERK/Nrf2 signaling pathway and MMP-7 expression involvement in the trigonelline-mediated inhibition of hepatocarcinoma cell migration
Background Trigonelline occurs in many dietary food plants and has been found to have anti-carcinogenic activity. Trigonelline is also found in coffee which is one of the most widely consumedExpand
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2-(Naphthalene-1-yl)-6-pyrrolidinyl-4-quinazolinone Inhibits Skin Cancer M21 Cell Proliferation through Aberrant Expression of Microtubules and the Cell Cycle
  • Y. Wu, M. J. Hour, +4 authors H. Lee
  • Biology, Medicine
  • Journal of Pharmacology and Experimental…
  • 1 September 2011
Microtubules are a proven target for anticancer drug development because they are critical for mitotic spindle formation and the separation of chromosomes at mitosis.Expand
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Identification of antioxidants from rhizome of Davallia solida
Abstract Davallia solida rhizome has long been used as an herb tonic to treat osteoporosis, arthralgia, and arthritis. The aqueous extract of D . solida rhizome contains a high content of phenolicExpand
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Amides from stems of annona cherimola
Abstract Four new amides, N - cis -caffeoyltyramine, dihydro-feruloyltyramine, N - trans -feruloylmethoxytyramine and N - cis -feruloylmethoxytyramine, along with two known amides, N - pExpand
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