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Automatic Morphological Subtyping Reveals New Roles of Caspases in Mitochondrial Dynamics
TLDR
An automated system for the quantification and classification of mitochondrial morphology is presented and new roles of Caspases in the regulatory mechanisms of mitochondrial dynamics are revealed, as well as applicable to the investigation of other subcellular organelle morphology. Expand
Bioactive constitutents from the stems of Annona montana.
TLDR
N-trans-Caffeoyltyramine is a new natural compound that was subjected to the antiplatelet aggregation and cytotoxicity bioassay where some of them showed significant activities. Expand
The oestrogenic and anti-platelet activities of dihydrobenzofuroisocoumarins and homoisoflavonoids from Liriope platyphylla roots.
TLDR
Several components exhibited significant oestrogenic and anti-platelet activities; demonstrating for the first time the potential use of L. platyphylla as a nutritional supplement for cardiovascular and endocrine diseases. Expand
3-Methyl-4,5-dihydro-oxepine, polyoxygenated seco-cyclohexenes and cyclohexenes from Uvaria flexuosa and their anti-inflammatory activity.
TLDR
Among the tested compounds, flexuvarol B and chrysin showed the most potent anti-inflammatory effect by inhibiting superoxide anion generation and elastase release from human neutrophils in response to fMLP with IC50 2.25-5.55μM. Expand
Identification of ent-16 beta, 17-dihydroxykauran-19-oic acid as an anti-HIV principle and isolation of the new diterpenoids annosquamosins A and B from Annona squamosa.
TLDR
Among these 14 compounds, 16 beta, 17-dihydroxy-ent-kauran-19-oic acid showed significant activity against HIV replication in H9 lymphocyte cells with an EC50 value of 0.8 microgram/mL (therapeutic index > 5). Expand
Acetogenins from Annonaceae.
TLDR
The aim of the present contribution is to summarize chemical and biological reports published since 1997 on annonaceous acetogenins and synthetic acetogenin mimics to summarize their cytotoxicity for cancer cell lines, neurotoxicity, pesticidal effects, and miscellaneous activities. Expand
Anti-inflammatory Cerebrosides from Cultivated Cordyceps militaris.
TLDR
The isolation of cerebrosides with anti-inflammatory activity from this TCM inhibited the accumulation of pro-inflammatory iNOS protein and reduced the expression of COX-2 protein in LPS-stimulated RAW264.7 macrophages. Expand
Two new natural azafluorene alkaloids and a cytotoxic aporphine alkaloid from Polyalthia longifolia.
TLDR
The stem and stem bark of Polyalthia longifolia afforded the cytotoxic aporphine alkaloid liriodenine and three azafluorene alkaloids, darienine, polyfothine, and isooncodine, which are new natural compounds. Expand
Cladielloides A and B: New Eunicellin-Type Diterpenoids from an Indonesian Octocoral Cladiella sp
TLDR
Two new eunicellin-type diterpenoids, cladielloides A and B, are found to possess a 2-hydroxybutyroxy group in their structures, which exhibited moderate cytotoxicity toward CCRF-CEM tumor cells and showed significant inhibitory effects on superoxide anion generation and elastase release by human neutrophils. Expand
Antrodia cinnamomea, a Treasured Medicinal Mushroom, Induces Growth Arrest in Breast Cancer Cells, T47D Cells: New Mechanisms Emerge
TLDR
The multiple targets of EEAC on breast cancer cells suggested that this extract may be developed as a potential dietary supplement targeting this debilitating disease. Expand
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