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FoxM1 promotes β-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis.
Wnt/β-catenin signaling is essential for stem cell regulation and tumorigenesis, but its molecular mechanisms are not fully understood. Here, we report that FoxM1 is a downstream component of WntExpand
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Estimating Divergence Parameters With Small Samples From a Large Number of Loci
Most methods for studying divergence with gene flow rely upon data from many individuals at few loci. Such data can be useful for inferring recent population history but they are unlikely to containExpand
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Heterodimers of Placenta Growth Factor/Vascular Endothelial Growth Factor
Here we show that the Escherichia coli expressed monomers of placenta growth factor (PLGF) and vascular endothelial growth factor (VEGF) can be re-folded in vitro to form PLGF/VEGF heterodimers. TheExpand
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On the origin of Lake Malawi cichlid species: A population genetic analysis of divergence
The cichlid fishes of Lake Malawi are famously diverse. However, phylogenetic and population genetic studies of their history have been difficult because of the great amount of genetic variation thatExpand
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Insulin Secretory Deficiency and Glucose Intolerance in Rab3A Null Mice*
Insulin secretory dysfunction of the pancreatic β-cell in type-2 diabetes is thought to be due to defective nutrient sensing and/or deficiencies in the mechanism of insulin exocytosis. PreviousExpand
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Matrix GLA Protein Modulates Differentiation Induced by Bone Morphogenetic Protein-2 in C3H10T1/2 Cells*
Matrix GLA protein (MGP) is ubiquitously expressed with high accumulation in bone and cartilage, where it was found to associate with bone morphogenetic proteins (BMP) during protein purification. ToExpand
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Characterization of LY2228820 Dimesylate, a Potent and Selective Inhibitor of p38 MAPK with Antitumor Activity
p38α mitogen-activated protein kinase (MAPK) is activated in cancer cells in response to environmental factors, oncogenic stress, radiation, and chemotherapy. p38α MAPK phosphorylates a number ofExpand
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The Induction of Yes-Associated Protein Expression After Arterial Injury Is Crucial for Smooth Muscle Phenotypic Modulation and Neointima Formation
Objective—Abnormal proliferation and migration of vascular smooth muscle cells (SMCs) are the key events in the progression of neointima formation in response to vascular injury. The goal of thisExpand
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Nuclear gene variation and molecular dating of the cichlid species flock of Lake Malawi.
The cichlid fishes of Lake Malawi are famously diverse. However, evolutionary studies have been difficult because of their recent and uncertain phylogenetic history. Portions of 12 nuclear loci wereExpand
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Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells
Despite advances in the differentiation of insulin-producing cells from human embryonic stem cells, the generation of mature functional β cells in vitro has remained elusive. To accomplish this goal,Expand
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