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Yersinia YopJ Acetylates and Inhibits Kinase Activation by Blocking Phosphorylation
Yersinia species use a variety of type III effector proteins to target eukaryotic signaling systems. The effector YopJ inhibits mitogen-activated protein kinase (MAPK) and the nuclear factor κB… Expand
Conservative Fragments in Bacterial 16S rRNA Genes and Primer Design for 16S Ribosomal DNA Amplicons in Metagenomic Studies
Bacterial 16S ribosomal DNA (rDNA) amplicons have been widely used in the classification of uncultured bacteria inhabiting environmental niches. Primers targeting conservative regions of the rDNAs… Expand
Integrated Profiling of MicroRNAs and mRNAs: MicroRNAs Located on Xq27.3 Associate with Clear Cell Renal Cell Carcinoma
Background With the advent of second-generation sequencing, the expression of gene transcripts can be digitally measured with high accuracy. The purpose of this study was to systematically profile… Expand
Quantification of increased cellularity during inflammatory demyelination.
Multiple sclerosis is characterized by inflammatory demyelination and irreversible axonal injury leading to permanent neurological disabilities. Diffusion tensor imaging demonstrates an improved… Expand
Total body irradiation selectively induces murine hematopoietic stem cell senescence.
Exposure to ionizing radiation (IR) and certain chemotherapeutic agents not only causes acute bone marrow (BM) suppression but also leads to long-term residual hematopoietic injury. This latter… Expand
Cell-specific Induction of Apoptosis by Microinjection of Cytochrome c
- F. Li, A. Srinivasan, Y. Wang, R. Armstrong, K. Tomaselli, L. Fritz
- Medicine, Biology
- The Journal of Biological Chemistry
- 28 November 1997
Bcl-xL, an antiapoptotic member of the Bcl-2 family, inhibits programmed cell death in a broad variety of cell types. Recent reports have demonstrated that cytochromec is released from mitochondria… Expand
Milnacipran for the treatment of fibromyalgia in adults: a 15-week, multicenter, randomized, double-blind, placebo-controlled, multiple-dose clinical trial.
BACKGROUND Preclinical and clinical studies have suggested that milnacipran, a dual norepinephrine-serotonin reuptake inhibitor, may be efficacious in the treatment of fibromyalgia (FM). OBJECTIVE… Expand
Total body irradiation causes residual bone marrow injury by induction of persistent oxidative stress in murine hematopoietic stem cells.
- Y. Wang, L. Liu, Senthil K Pazhanisamy, H. Li, Aimin Meng, D. Zhou
- Medicine, Chemistry
- Free radical biology & medicine
- 15 January 2010
Ionizing radiation (IR) and/or chemotherapy causes not only acute tissue damage but also late effects including long-term (or residual) bone marrow (BM) injury. The induction of residual BM injury is… Expand
Carbon Monoxide Protects against Hyperoxia-induced Endothelial Cell Apoptosis by Inhibiting Reactive Oxygen Species Formation*
- X. Wang, Y. Wang, H. Kim, K. Nakahira, S. Ryter, A. Choi
- Medicine, Biology
- Journal of Biological Chemistry
- 19 January 2007
Hyperoxia causes cell injury and death associated with reactive oxygen species formation and inflammatory responses. Recent studies show that hyperoxia-induced cell death involves apoptosis,… Expand
Genotypes and Mouse Virulence of Toxoplasma gondii Isolates from Animals and Humans in China
Background Recent population structure studies of T. gondii revealed that a few major clonal lineages predominated in different geographical regions. T. gondii in South America is genetically and… Expand