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Prostaglandin E2 receptor subtype 2 (EP2) regulates microglial activation and associated neurotoxicity induced by aggregated α-synuclein
TLDR
It appears that microglial EP2 plays a critical role in α-synuclein-mediated neurotoxicity, and reduced neurotoxicity by EP2-/- microglia could be attributed to suppressed translocation of a critical cytoplasmic subunit (p47-phox) of NADPH oxidase to the membranous compartment after exposure to aggregated α- synuclein. Expand
Arthroscopic Gluteal Muscle Contracture Release With Radiofrequency Energy
TLDR
Gluteal muscle contracture could be released effectively with radiofrequency energy and no hip abductor contracture recurred and no patient had residual hip pain or gluteal Muscle wasting. Expand
Arachidonic Acid Epoxygenase Metabolites Stimulate Endothelial Cell Growth and Angiogenesis via Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase/Akt Signaling Pathways
TLDR
It is concluded that AA epoxygenase metabolites can promote angiogenesis, which may provide protection to ischemic tissues and the angiogenic effects of EETs involve the MAPK and PI3-kinase/Akt signaling pathways, and to some extent, the eNOS pathway. Expand
Short interfering RNA directed against TWIST, a novel zinc finger transcription factor, increases A549 cell sensitivity to cisplatin via MAPK/mitochondrial pathway.
TLDR
It is shown that TWIST depletion significantly sensitized A549 cells to cisplatin by inducing activation of JNK/mitochondrial pathway but not ERK and p-38 pathways, suggesting critical roles of TWIST in A549 cell chemoresistance to cis Platin and raising the possibility of TWist depletion as a promising approach to lung cancer therapy. Expand
Polymorphism of tumor necrosis factor alpha (TNF-alpha) gene promoter, circulating TNF-alpha level, and cardiovascular risk factor for ischemic stroke
TLDR
In vitro evaluation of potential interaction between variants of the TNF-α gene (−308G/A, -857C/T, and -1031T/C) demonstrated that these three polymorphisms could interact together to determine the overall activity of theTNF- α gene. Expand
Effects of Varying Degrees of Intermittent Hypoxia on Proinflammatory Cytokines and Adipokines in Rats and 3T3-L1 Adipocytes
TLDR
Oxidative stress and the release of pro-inflammatory cytokines/adipokines, which are the systemic inflammatory markers, are associated with IH closely and are proportional to the severity of IH. Expand
C-Reactive Protein-Induced Endothelial Microparticle Generation in HUVECs Is Related to BH4-Dependent NO Formation
TLDR
This study demonstrates that CRP induces EMP generation in HUVECs and this effect is, at least in part, related to impaired BH4-dependent NO production. Expand
Unilateral versus bilateral balloon kyphoplasty in the treatment of osteoporotic vertebral compression fractures.
TLDR
The unilateral approach should be considered an effective option for the treatment of osteoporotic vertebral compression fractures because it resulted in pain relief and vertebral height and kyphotic angle restoration comparable with that of bilateral kYphoplasty. Expand
Total Hip Arthroplasty Versus Hemiarthroplasty for Displaced Femoral Neck Fractures: Meta-analysis of Randomized Trials
TLDR
Despite more dislocations, THA can benefit patients with displaced femoral neck fractures with a lower reoperation rate and higher functional scores. Expand
Plasma microRNA-133a is a new marker for both acute myocardial infarction and underlying coronary artery stenosis
TLDR
Circulating miR-133a may be a new biomarker for AMI and as a potential diagnostic tool that may be used to predict both the presence and severity of coronary lesions in CHD patients. Expand
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