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A Structured Viroid RNA Serves as a Substrate for Dicer-Like Cleavage To Produce Biologically Active Small RNAs but Is Resistant to RNA-Induced Silencing Complex-Mediated Degradation
The hypothesis that some infectious RNAs may have evolved specific secondary structures as an effective means to evade RNA silencing in addition to encoding silencing suppressor activities is supported. Expand
PLGA nanoparticles improve the oral bioavailability of curcumin in rats: characterizations and mechanisms.
The results showed that the effect in improving oral bioavailability of CUR may be associated with improved water solubility, higher release rate in the intestine juice, enhanced absorption by improved permeability, inhibition of P-glycoprotein (P-gp)-mediated efflux, and increased residence time in the intestinal cavity. Expand
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism
The genomic information of A. mediterranei demonstrates a metabolic network orchestrated not only for extensive utilization of various carbon sources and inorganic nitrogen compounds but also for effective funneling of metabolic intermediates into the secondary antibiotic synthesis process under the control of a seemingly complex regulatory mechanism. Expand
A geminivirus-based guide RNA delivery system for CRISPR/Cas9 mediated plant genome editing
A virus-based guide RNA (gRNA) delivery system for CRISPR/Cas9 mediated plant genome editing (VIGE) that can be used to precisely target genome locations and cause mutations is reported. Expand
Accumulation of Potato spindle tuber viroid-specific small RNAs is accompanied by specific changes in gene expression in two tomato cultivars.
Large-scale sequence analysis of viroid-specific small RNAs revealed active production from the upper portion of the pathogenicity and central domains, two regions previously thought to be underrepresented. Expand
FLP-FRT-Based Method To Obtain Unmarked Deletions of CHU_3237 (porU) and Large Genomic Fragments of Cytophaga hutchinsonii
An efficient method based on a linear DNA double-crossover and FLP-FRT recombination system to obtain unmarked deletions of both single genes and large genomic fragments in C. hutchinsonii resulted in defects in colony spreading, cellulose degradation, and protein secretion, indicating that it is a component of the T9SS. Expand
Genetic drift of human coronavirus OC43 spike gene during adaptive evolution
It is suggested that the genetic drift of the S gene may play an important role in genotype persistence in human populations, providing insights into the mechanisms of HCoV-OC43 adaptive evolution. Expand
Ectopic expression of miR156 represses nodulation and causes morphological and developmental changes in Lotus japonicus
The results show that miR 156 regulates vegetative biomass yield, flowering time and nodulation by silencing downstream target SPLs and other genes, suggesting that the miR156 regulatory network could be modified in forage legumes and in leafy vegetables to positively impact economically valuable crop species. Expand
Establishment of a xylose metabolic pathway in an industrial strain of Saccharomyces cerevisiae
To produce an industrial strain of Saccharomyces cerevisiae that metabolizes xylose, we constructed a rDNA integration vector and YIp integration vector, containing the xylose-utilizing genes, XYL1Expand
Angiogenic microspheres promote neural regeneration and motor function recovery after spinal cord injury in rats
It is suggested that biodegradable, biocompatible PLGA microspheres can release angiogenic factors in a sustained fashion into sites of spinal cord injury and markedly stimulate angiogenesis and neurogenesis, accelerating recovery of neurologic function. Expand