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The cloning and expression of a human creatine transporter.
Transient expression of the hCRT-BS2M in COS-7 cells demonstrates sodium dependent [14C]creatine uptake with a KM value of 14.9 +/- 3.0 microM that is attenuated by creatine and selective structural analogues of creatine. Expand
Does the Production of an Airbag Injure More People than the Airbag Saves in Traffic?
Social life cycle assessment (S-LCA) has been discussed for some years in the LCA community. We raise two points of criticism against current S-LCA approaches. First, the development of S-LCAExpand
HIPK2 associates with RanBPM.
It is shown that overexpressed wildtype HIPK2 and a kinase defective mutant of HIPK1 directly interact with RanBPM in the nucleus of mammalian cells and co-localise with HIPK 2 in defined nuclear structures. Expand
Orphan G protein-coupled receptors (GPCRs): biological functions and potential drug targets
This review focuses on the signaling transduction pathways of the adhesion GPCR family, the LGR sub family, and the PSGR subfamily, and their potential functions in immunology, development, and cancers. Expand
Bone morphogenetic protein 2 stimulates noncanonical SMAD2/3 signaling via the BMP type 1A receptor in gonadotrope-like cells: implications for FSH synthesis.
The data challenge current dogma that ALK3 and other BMP type I receptors signal via SMAD1, SMAD5, and SMAD8 and not SMAD2 or SMAD3 and suggest that BMPs and activins may use similar intracellular signaling mechanisms to activate the murine Fshb promoter in immortalized gonadotrope-like cells. Expand
Mechanism of CYP2C9 Inhibition by Flavones and Flavonols
Flavonoids can participate in interactions with drugs that act as substrates for CYP2C9 and provide a possible molecular basis for understanding cooperativity in human P450-mediated drug-drug interactions. Expand
The mediating role of inclusive leadership: Work engagement and innovative behaviour among Chinese head nurses.
Work engagement affects innovative behaviour among Chinese head nurses, and inclusive leadership is a mediator in the relationship. Expand
Distribution and clinical features of Paragonimiasis skrjabini in Three Gorges Reservoir Region.
Results show that the Three Gorges Reservoir is still an area of high paragonimiasis endemicity and the water level of the Yangtze River has risen to 175 m, and the area of water coverage in the region has increased to 1084 km(2). Expand
Osteoporosis in China
Overall, the prevalence of osteoporosis among these Chinese populations remains low compared to other Caucasian populations; in the mainland, it was approximately 13%. Expand
The effect of the mtDNA4834 deletion on hearing.
The results show that accelerated aging in the inner ear of the rat could be induced by injecting d-galactose, and suggest that mtDNA4834 deletion can not directly induce the hearing loss, but acting as a predisposing factor which can greatly enhance the sensitivity of the innerEar to the aminoglycoside antibiotic. Expand