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Computational Identification of Protein Methylation Sites through Bi-Profile Bayes Feature Extraction
Protein methylation is one type of reversible post-translational modifications (PTMs), which plays vital roles in many cellular processes such as transcription activity, DNA repair. ExperimentalExpand
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α-Synuclein, a chemoattractant, directs microglial migration via H2O2-dependent Lyn phosphorylation
Significance α-Synuclein (α-syn) aggregates released from neurons activate microglia, leading to chronic neuroinflammation that causes damage to neurons in brains with synucleinopathies, such asExpand
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Nutritional and Chemical Composition and Antiviral Activity of Cultivated Seaweed Sargassum naozhouense Tseng et Lu
Sargassum naozhouense is a brown seaweed used in folk medicine and applied for thousands of years in Zhanjiang, Guangdong province, China. This study is the first time to investigate its chemicalExpand
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Epidermal Growth Factor Receptor-PI3K Signaling Controls Cofilin Activity To Facilitate Herpes Simplex Virus 1 Entry into Neuronal Cells
ABSTRACT Herpes simplex virus type 1 (HSV-1) establishes latency in neurons and can cause severe disseminated infection with neurological impairment and high mortality. This neurodegeneration isExpand
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Systematic analysis of human lysine acetylation proteins and accurate prediction of human lysine acetylation through bi-relative adapted binomial score Bayes feature representation.
Lysine acetylation is a reversible post-translational modification (PTM) which has been linked to many biological and pathological implications. Hence, localization of lysine acetylation is essentialExpand
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Cofilin 1-Mediated Biphasic F-Actin Dynamics of Neuronal Cells Affect Herpes Simplex Virus 1 Infection and Replication
ABSTRACT Herpes simplex virus 1 (HSV-1) invades the nervous system and causes pathological changes. In this study, we defined the remodeling of F-actin and its possible mechanisms during HSV-1Expand
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Identification of a silencer, enhancer, and basal promoter region in the human CD95 (Fas/APO-1) gene.
Genomic clones for the human CD95 (Fas/APO-1) and CD40 genes have been isolated and 2.3 kb of the CD95 and 0.8 kb of the CD40 gene 5'-flanking regions sequenced. Comparisons of the human CD95 geneExpand
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Viruses exploit the function of epidermal growth factor receptor
Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that regulates cellular homeostatic processes. Following ligand binding, EGFR activates different downstream signalling cascadesExpand
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Regional Ischemic Vulnerability of the Brain to Hypoperfusion: The Need for Location Specific Computed Tomography Perfusion Thresholds in Acute Stroke Patients
Background and Purpose— To characterize the spatial pattern of cerebral ischemic vulnerability to hypoperfusion in stroke patients. Methods— We included 90 patients who underwent admission CTExpand
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Follistatin-Like 1: A Potential Mediator of Inflammation in Obesity
Obesity is associated with a state of chronic low-grade inflammation, which contributes to insulin resistance and type 2 diabetes. However, the molecular mechanisms that link obesity to inflammationExpand
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