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Pharmacological Rescue of Synaptic Plasticity, Courtship Behavior, and Mushroom Body Defects in a Drosophila Model of Fragile X Syndrome
Fragile X syndrome is a leading heritable cause of mental retardation that results from the loss of FMR1 gene function. A Drosophila model for Fragile X syndrome, based on the loss of dfmr1 activity,… Expand
Detection of biomarkers with a multiplex quantitative proteomic platform in cerebrospinal fluid of patients with neurodegenerative disorders.
Biomarkers are needed to assist in the diagnosis and medical management of various neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease (PD), and dementia with Lewy… Expand
Proteomic Identification of a Stress Protein, Mortalin/mthsp70/GRP75
- Jinghua Jin, C. Hulette, +4 authors J. Zhang
- Medicine, Biology
- Molecular & Cellular Proteomics
- 1 July 2006
Functional impairment of mitochondria and proteasomes and increased oxidative damage comprise the main pathological phenotypes of Parkinson disease (PD). Using an unbiased quantitative proteomic… Expand
Subgenome parallel selection is associated with morphotype diversification and convergent crop domestication in Brassica rapa and Brassica oleracea
Brassica species, including crops such as cabbage, turnip and oilseed, display enormous phenotypic variation. Brassica genomes have all undergone a whole-genome triplication (WGT) event with unknown… Expand
Long non-coding RNAs: versatile master regulators of gene expression and crucial players in cancer.
- Lei Nie, Hsing-Ju Wu, +6 authors M. Hung
- Biology, Medicine
- American journal of translational research
With rapid development of sequencing technologies such as deep sequencing and whole genome high-density tiling array, we now know that most of the "junk" genomic sequences are transcribed as… Expand
Fragile X protein functions with lgl and the par complex in flies and mice.
Fragile X syndrome, the most common form of inherited mental retardation, is caused by loss of function for the Fragile X Mental Retardation 1 gene (FMR1). FMR1 protein (FMRP) has specific mRNA… Expand
Intrinsic Epigenetic Factors Cooperate with the Steroid Hormone Ecdysone to Govern Dendrite Pruning in Drosophila
Pruning that selectively removes unnecessary axons/dendrites is crucial for sculpting neural circuits during development. During Drosophila metamorphosis, dendritic arborization sensory neurons,… Expand
Identification of Novel Proteins Associated with Both α-Synuclein and DJ-1*S
The molecular mechanisms leading to neurodegeneration in Parkinson disease (PD) remain elusive, although many lines of evidence have indicated that α-synuclein and DJ-1, two critical proteins in PD… Expand
Radioprotective and Antioxidant Effect of Resveratrol in Hippocampus by Activating Sirt1
- J. Li, L. Feng, +8 authors F. Fan
- Biology, Medicine
- International journal of molecular sciences
- 1 April 2014
Reactive oxygen species can lead to functional alterations in lipids, proteins, and nucleic acids, and an accumulation of ROS (Reactive oxygen species) is considered to be one factor that contributes… Expand
MLPA-based genotype–phenotype analysis in 1053 Chinese patients with DMD/BMD
BackgroundLarge-scale analysis of the transmission, mutation characteristics and the relationship between the reading frame and phenotype of the DMD gene has previously been performed in several… Expand