• Publications
  • Influence
Anticancer Peptidylarginine Deiminase (PAD) Inhibitors Regulate the Autophagy Flux and the Mammalian Target of Rapamycin Complex 1 Activity*
Background: Histone citrullination by PAD4 regulates tumor suppressor gene expression. Results: The novel PAD inhibitor YW3-56 inhibits cancerous growth by perturbing autophagy and regulating theExpand
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The involvement of follistatin-like protein 1 in osteoarthritis by elevating NF-κB-mediated inflammatory cytokines and enhancing fibroblast like synoviocyte proliferation
IntroductionOur previous work has revealed that expression of follistatin-like protein 1 (FSTL1) is elevated in the synovial tissues from osteoarthritis (OA) patients. The aim of this study was toExpand
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  • Open Access
Hidden blood loss and its influential factors after total hip arthroplasty
BackgroundTotal hip arthroplasty (THA) is a vital therapy for various hip joint diseases. However, patients have lower hemoglobin level post-operatively, remarkably inconsistent with the measuredExpand
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Oxidative stress in osteoarthritis and antioxidant effect of polysaccharide from angelica sinensis.
This study aimed to investigate the oxidative stress in human osteoarthritis (OA) chondrocytes and the antioxidant effect of angelica sinensis polysaccharide (ASP) on it. Human OA chondrocytes andExpand
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Pyranoflavones: a group of small-molecule probes for exploring the active site cavities of cytochrome P450 enzymes 1A1, 1A2, and 1B1.
Selective inhibition of P450 enzymes is the key to block the conversion of environmental procarcinogens to their carcinogenic metabolites in both animals and humans. To discover highly potent andExpand
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MDM4 overexpression contributes to synoviocyte proliferation in patients with rheumatoid arthritis.
  • N. Xu, Y. Wang, +7 authors T. Dong
  • Medicine, Biology
  • Biochemical and biophysical research…
  • 22 October 2010
Rheumatoid arthritis (RA) is a chronic autoimmune disease with features of inflammatory cell infiltration, synovial cell invasive proliferation, and ultimately, irreversible joint destruction. It hasExpand
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A class of oral N-[(1S,3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carbonyl]- N'-(amino-acid-acyl)hydrazine: discovery, synthesis, in vitro anti-platelet aggregation/in vivo anti-thrombotic
  • K. Yao, M. Zhao, +4 authors S. Peng
  • Medicine, Chemistry
  • European journal of medicinal chemistry
  • 1 August 2011
The in vivo anti-thrombotic activities of amino acid modified tetrahydro-β-carbolines depended upon the proximity of the side chain of the amino acid residue to the carboline-cycle. Based on thisExpand
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Follistatin-like protein 1: a serum biochemical marker reflecting the severity of joint damage in patients with osteoarthritis
IntroductionFollistatin-like protein 1 (FSTL1) is a secreted glycoprotein that has been implicated in arthritis pathogenesis in a mouse model. The aim of this study is to detect FSTL1 expression andExpand
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In vitro inhibition of fatty acid synthase by 1,2,3,4,6-penta-O-galloyl-β-D-glucose plays a vital role in anti-tumour activity.
1,2,3,4,6-Penta-O-galloyl-β-D-glucose (PGG) inhibits glioma cancer U251 cells, more strongly than MDA-MB-231 and U87 cells. In addition, PGG is transported across cancer cell membrane to furtherExpand
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Distributed six degree-of-freedom spacecraft formation control with possible switching topology
This work studies distributed six degree-of-freedom spacecraft formation control with possible switching topology. By rearranging the combined translational and rotational dynamics into a unifiedExpand
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