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Phosphatidylinositol 4,5-Bisphosphate Rescues TRPM4 Channels from Desensitization*
TRPM4 is a Ca2+-activated nonselective cation channel that regulates membrane potential in response to intracellular Ca2+ signaling. In lymphocytes it plays an essential role in shaping the patternExpand
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Transcriptional Blood Signatures Distinguish Pulmonary Tuberculosis, Pulmonary Sarcoidosis, Pneumonias and Lung Cancers
Rationale New approaches to define factors underlying the immunopathogenesis of pulmonary diseases including sarcoidosis and tuberculosis are needed to develop new treatments and biomarkers.Expand
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Visualizing of the cellular uptake and intracellular trafficking of exosomes by live‐cell microscopy
Cells release exosomes to transfer various molecules to other cells. Exosomes are involved in a number of physiological and pathological processes. They are emerging great potential utility forExpand
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Matrix Metalloproteinase-2 and -9 Secreted by Leukemic Cells Increase the Permeability of Blood-Brain Barrier by Disrupting Tight Junction Proteins
Central nervous system (CNS) involvement remains an important cause of morbidity and mortality in acute leukemia, the mechanisms of leukemic cell infiltration into the CNS have not yet beenExpand
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Endemic fluorosis of the skeleton: radiographic features in 127 patients.
OBJECTIVE A wide range of radiographic appearances have been reported in skeletal fluorosis, but little has been written about the spectrum of radiographic features. We evaluated the spectrum ofExpand
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Evaluation of MAGE-1 and MAGE-3 as tumour-specific markers to detect blood dissemination of hepatocellular carcinoma cells
The members of MAGE gene family are highly expressed in human hepatocellular carcinoma (HCC). In the present study, we tested the tumour-specific MAGE-1 and MAGE-3 transcripts in the peripheral bloodExpand
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A genome-wide survey of copy number variation regions in various chicken breeds by array comparative genomic hybridization method.
The discovery of copy number variation (CNV) in the genome has provided new insight into genomic polymorphism. Studies with chickens have identified a number of large CNV segments using a 385kExpand
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A single nucleotide polymorphism at the Vrn-D1 promoter region in common wheat is associated with vernalization response
Facultative wheat varieties adapt to a particular environment. But the molecular basis for the facultative growth habit is not clear relative to winter and spring growth habit. Two sets of wheatExpand
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Clostridial gas gangrene. I. Cellular and molecular mechanisms of microvascular dysfunction induced by exotoxins of Clostridium perfringens.
Mechanisms responsible for the rapid tissue destruction in gas gangrene are not well understood. To examine the early effects of Clostridium perfringens exotoxins on tissue perfusion, a rat model ofExpand
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Hepatitis C virus RNA and antibodies among blood donors in Beijing.
Blood units from voluntary as well as commercial donors in Beijing, China, were tested for hepatitis C virus RNA and antibodies, and for serological markers of hepatitis B virus infection. HCV RNAExpand
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