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Fringe is a glycosyltransferase that modifies Notch
Notch receptors function in highly conserved intercellular signalling pathways that direct cell-fate decisions, proliferation and apoptosis in metazoans. Fringe proteins can positively and negativelyExpand
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Expansion of C4 ecosystems as an indicator of global ecological change in the late Miocene
THE most common and the most primitive pathway of the three different photosynthetic pathways used by plants is the C3 pathway, or Calvin cycle, which is characterized by an initial CO2 carboxylationExpand
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Carbon isotopes in soils and palaeosols as ecology and palaeoecology indicators
THERE are few quantitative techniques in use today for palaeoecological reconstruction in terrestrial depositional systems. One approach to such reconstructions is to estimate the proportion of C3 toExpand
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MiR-133a in Human Circulating Monocytes: A Potential Biomarker Associated with Postmenopausal Osteoporosis
Background Osteoporosis mainly occurs in postmenopausal women, which is characterized by low bone mineral density (BMD) due to unbalanced bone resorption by osteoclasts and formation by osteoblasts.Expand
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Transcriptome Profiling of Testis during Sexual Maturation Stages in Eriocheir sinensis Using Illumina Sequencing
The testis is a highly specialized tissue that plays dual roles in ensuring fertility by producing spermatozoa and hormones. Spermatogenesis is a complex process, resulting in the production ofExpand
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MiR-422a as a Potential Cellular MicroRNA Biomarker for Postmenopausal Osteoporosis
Background MicroRNAs (miRNAs) are a class of short non-coding RNA molecules that regulate gene expression by targeting mRNAs. Recently, miRNAs have been shown to play important roles in the etiologyExpand
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A New Exhaustive Method and Strategy for Finding Motifs in ChIP-Enriched Regions
ChIP-seq, which combines chromatin immunoprecipitation (ChIP) with next-generation parallel sequencing, allows for the genome-wide identification of protein-DNA interactions. This technology posesExpand
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A 32 kb Critical Region Excluding Y402H in CFH Mediates Risk for Age-Related Macular Degeneration
Complement factor H shows very strong association with Age-related Macular Degeneration (AMD), and recent data suggest that multiple causal variants are associated with disease. To refine theExpand
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A Method for WD40 Repeat Detection and Secondary Structure Prediction
WD40-repeat proteins (WD40s), as one of the largest protein families in eukaryotes, play vital roles in assembling protein-protein/DNA/RNA complexes. WD40s fold into similar β-propeller structuresExpand
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Specific Marker Expression and Cell State of Schwann Cells during Culture In Vitro
Schwann cells (SCs) in animals exist in different developmental stages or wound repair phases, distinguished mainly by the expression of SC-specific markers. No study has yet determined SC stateExpand
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