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The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development.
It is suggested that activation of the HIF alpha pathway in developing bone increases bone modeling events through cell-nonautonomous mechanisms to coordinate the timing, direction, and degree of new blood vessel formation in bone. Expand
A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice
Resveratrol, at doses that can be readily achieved in humans, fulfills the definition of a dietary compound that mimics some aspects of CR, andGene expression profiling suggests that both CR and resver atrol may retard some aspect of aging through alterations in chromatin structure and transcription. Expand
Mutation Profiling in Cholangiocarcinoma: Prognostic and Therapeutic Implications
GAs in the chromatin modulating genes, BAP1 and PBRM1 were associated with bone metastases and worse survival in extrahepatic CCA, and NGS can potentially identify disease subsets with distinct prognostic and therapeutic implications. Expand
Activated Neural Stem Cells Contribute to Stroke-Induced Neurogenesis and Neuroblast Migration toward the Infarct Boundary in Adult Rats
Findings indicate that in the adult stroke brain, increases in recruitment of neural stem cells contribute to stroke-induced neurogenesis, and that newly generated neurons migrate from the SVZ to the ischemic striatum. Expand
Treatment of Stroke With Erythropoietin Enhances Neurogenesis and Angiogenesis and Improves Neurological Function in Rats
The data suggest that EPO-increased VEGF and BDNF may be involved in angiogenesis and neurogenesis, which could contribute to functional recovery. Expand
Stromal cell-derived factor 1alpha mediates neural progenitor cell motility after focal cerebral ischemia.
Findings show that SDF-1alpha generated in the stroke hemisphere may guide NPC migration towards the ischemic boundary via binding to its receptor CXCR 4 in the NPC. Expand
Role of Toll-Like Receptor 4 in Endotoxin-Induced Acute Renal Failure 1
The hypothesis that LPS acts on extrarenal TLR4, thereby leading to systemic TNF release and subsequent ARF is supported, which is potential mechanisms by which endotoxemia leads to functional ARF. Expand
The regulation of T cell homeostasis and autoimmunity by T cell-derived LIGHT.
  • J. Wang, J. Lo, +6 authors Y. Fu
  • Biology, Medicine
  • The Journal of clinical investigation
  • 15 December 2001
It is demonstrated that blockade of LIGHT activity can reduce anti-CD3-mediated proliferation of purified T cells, suggesting that T cell-T cell interaction is essential for this proliferation, and establishes a crucial role for this Tcell-derived costimulatory ligand in T cell activation and expansion. Expand
Analyses of CIA5, the master regulator of the carbon-concentrating mechanism in Chlamydomonas reinhardtii, and its control of gene expression
It is demonstrated that cycloheximide (an inhibitor of cytoplasmic protein synthesis) has no apparent effect on the initial induction of CO2-responsive genes, suggesting constitutive presence of all the molecular machinery needed by the cell to immediately respond to changes in CO2 levels. Expand
Screening diabetic transplant candidates for coronary artery disease: identification of a low risk subgroup.
Coronary artery disease should be recommended to Caucasian type I diabetic renal transplant candidates age 45 or older because of the high probability of disease, and in patients younger than 45 without a smoking history, ST-T wave changes on EKG, or diabetes longer than 25 years, the likelihood of CAD is low and angiography can be avoided. Expand