• Publications
  • Influence
Curcumin-loaded biodegradable polymeric micelles for colon cancer therapy in vitro and in vivo.
Curcumin is an effective and safe anticancer agent, but its hydrophobicity inhibits its clinical application. Nanotechnology provides an effective method to improve the water solubility ofExpand
  • 289
  • 5
Ursolic acid attenuates lipopolysaccharide-induced acute lung injury in a mouse model.
AIM To assess whether ursolic acid (UA) can attenuate lipopolysachharide (LPS)-induced acute lung injury and improve the survival time in a mouse model. MATERIALS & METHODS The mice were challengedExpand
  • 16
  • 2
Assessment of hematopoietic failure due to Rpl11 deficiency in a zebrafish model of Diamond-Blackfan anemia by deep sequencing
BackgroundDiamond–Blackfan anemia is a rare congenital red blood cell dysplasia that develops soon after birth. RPL11 mutations account for approximately 4.8% of human DBA cases with defectiveExpand
  • 19
  • 2
  • PDF
CHANGES OF GOLGI APPARATUS DURING SPERMATOGENESIS OF MACROBRACHIUM NIPPONENSE
The changes of Golgi apparatus during spermatogenesis of Macrobrachium nipponense were studied with transmission electron microscopy (TEM) . The results show that, there are typical Golgi apparatusExpand
  • 12
  • 2
Antiangiogenic Therapy Using Sunitinib Combined with Rapamycin Retards Tumor Growth But Promotes Metastasis1
BACKGROUND: This study investigated the synergistic effect of sunitinib and rapamycin on tumor growth and metastasis in murine breast cancer model. METHODS: The synergistic antitumor effect ofExpand
  • 15
  • 2
Transcriptome analysis of Rpl11-deficient zebrafish model of Diamond-Blackfan Anemia
To comprehensively reflect the roles of Rpl11 on the transcriptome of zebrafish model of Diamond-Blackfan Anemia (DBA), we performed whole-genome transcriptome sequencing on the Illumina Hi-Seq 2000Expand
  • 4
  • 2
Enhanced interaction between natural killer cells and lung cancer cells: involvement in gefitinib-mediated immunoregulation
BackgroundNatural killer (NK) cells can kill tumor cells in a non-MHC-restricted manner. However, cancer cells frequently escape from the attack of NK cells by multiple ways. In this study, weExpand
  • 46
  • 1
In Vitro and In Vivo Activities of Antimicrobial Peptides Developed Using an Amino Acid-Based Activity Prediction Method
ABSTRACT To design and discover new antimicrobial peptides (AMPs) with high levels of antimicrobial activity, a number of machine-learning methods and prediction methods have been developed. Here, weExpand
  • 40
  • 1
  • PDF
Intron 1 GATA site enhances ALAS2 expression indispensably during erythroid differentiation
The first intronic mutations in the intron 1 GATA site (int-1-GATA) of 5-aminolevulinate synthase 2 (ALAS2) have been identified in X-linked sideroblastic anemia (XLSA) pedigrees, strongly suggestingExpand
  • 12
  • 1
  • PDF
PNAS-4, an Early DNA Damage Response Gene, Induces S Phase Arrest and Apoptosis by Activating Checkpoint Kinases in Lung Cancer Cells*
Background: Elevated PNAS-4 induces S phase arrest and apoptosis in vitro and inhibits tumor growth in vivo. Results: PNAS-4 activates Chk1/2 to cause inhibition of the Cdc25A-CDK2-cyclin E/AExpand
  • 25
  • PDF