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Electrical fingerprinting, 3D profiling and detection of tumor cells with solid-state micropores.
TLDR
The device does not require any preprocessing of the blood sample, particles/beads attachment, surface functionalization or fluorescent tags and provides quantitative and objective detection of cancer cells and enables detection of tumor cells from whole blood efficiently.
Surface-immobilized aptamers for cancer cell isolation and microscopic cytology.
TLDR
The findings show how novel aptamer substrates could be used to determine whether surgical resection margins are free of tumor cells, or more widely for detecting tumor cells circulating in peripheral blood to improve early detection and/or monitoring residual disease after treatment.
Nanotextured substrates with immobilized aptamers for cancer cell isolation and cytology
TLDR
Improving the affinity of a selective, surface‐functionalized molecule is important given the scarcity of CTCs in vivo, and using surface nanotexturing increases this affinity even further.
Effects of nanopillar array diameter and spacing on cancer cell capture and cell behaviors.
TLDR
The results show a linear relationship between the cell capture yield and effective contact area of NP substrates where a NP array of small diameter and reasonable spacing is preferred; however, spacing that is too small or too large adversely impairs the capture efficiency and specificity, respectively.
Preparation of Engineered Extracellular Vesicles Derived from Human Umbilical Cord Mesenchymal Stem Cells with Ultrasonication for Skin Rejuvenation
TLDR
Development of engineered EVs (eEV) derived from human umbilical cord mesenchymal stem cells (hucMSCs) for skin treatment with higher yield and faster production indicate that hucMSC-derived eEVs prepared by ultrasonication potentially can be used to increase skin extracellular matrix and enhance skin rejuvenation.
Self-Assembly of Extracellular Vesicle-like Metal-Organic Framework Nanoparticles for Protection and Intracellular Delivery of Biofunctional Proteins.
TLDR
In vitro and in vivo study manifests that the EV-like nanoparticles can not only protect proteins against protease digestion and evade the immune system clearance but also selectively target homotypic tumor sites and promote tumor cell uptake and autonomous release of the guest protein after internalization.
Nucleic acid aptamers in cancer research, diagnosis and therapy.
TLDR
Aptamers are single-stranded DNA or RNA oligomers, identified from a random sequence pool, with the ability to form unique and versatile tertiary structures that bind to cognate molecules with superior specificity, that enable them to rival antibodies in cancer imaging and therapy applications.
Mitochondria-Targeting Polydopamine Nanoparticles To Deliver Doxorubicin for Overcoming Drug Resistance.
TLDR
The results indicate the promising potential of applying PDA-PEG-TPP-DOX nanoparticles in mitochondria-targeted drug delivery to overcome the drug resistance in long-time anticancer chemotherapy.
Capture, isolation and release of cancer cells with aptamer-functionalized glass bead array.
TLDR
The use of highly selective anti-EGFR aptamer with the glass beads in an array and subsequent release of cells with antisense molecules provide multiple levels of binding and release opportunities that can help in defining new classes of CTC enumeration devices.
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