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Structure-activity relations of azafluorenone and azaanthraquinone as antimicrobial compounds.
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Growth inhibition dependent on reactive oxygen species generated by C9-UK-2A, a derivative of the antifungal antibiotic UK-2A, in Saccharomyces cerevisiae.
TLDR
The results suggest that C9-UK-2A induces ROS generation due to the blockade of electron flow at complex III, thereby inhibiting the growth of S. cerevisiae in SD medium.
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P-503 Synthetic Studies on Spirostomin, a Defense Toxin of Spirostomum teres
Structure-activity relationship studies on UK-2A, a novel antifungal antibiotic from Streptomyces sp. 517-02. Part 5: Roles of the 9-membered dilactone-ring moiety in respiratory inhibition.
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A new synthesis of α-fluoro-α,β-unsaturated ketones and esters based on organoselenium methodology
TLDR
Fluoroselenenylation of α-diazoketones and α- diazoesters using a phenylselenenyl fluoride equivalent provided α-fluoro-α,β-unsaturated ketones and ester, respectively, in moderate yields.
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Rhodium(III)-catalyzed β-Arylation and -Alkenylation of α-Trifluoromethylacrylic Acid
The β-arylation and -alkenylation of trifluoromethylacrylic acid with arylboronic acids and alkenes proceed smoothly under rhodium(III) catalysis. The procedures provide useful synthetic routes fro...
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UK-2A, B, C, and D, novel antifungal antibiotics from Streptomyces sp. 517-02 VII. Membrane injury induced by C9-UK-2A, a derivative of UK-2A, in Rhodotorula mucilaginosa IFO 0001.
TLDR
Results suggest a membrane injury caused by C9-UK-2A in R. mucilaginosa IFO 0001, the most potent and durable antifungal activities against a strict aerobic yeast.
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Iridium-Catalyzed Aerobic Coupling of Salicylaldehydes with Alkynes: A Remarkable Switch of Oxacyclic Product.
TLDR
DFT calculations suggest that this unique transformation involves the facile deinsertion of CO in the key metallacycle intermediate, which is in marked contrast to the corresponding rhodium(III) catalysis that leads to CO-retentive chromone derivatives.
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SYNTHESIS OF UK-3A ANALOGUE AND ASSAY ON P 388 MURINE LEUKEMIA CELLS
TLDR
An analogue of UK-3A was synthesized from L-methyl serine as the starting material by amidation and esterification and found to have IC50 15.4μg/mL against the same Leukemia cells.
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Fluoroselenenylation of alkenes.
Benzeneselenenyl fluoride equivalent was generated in situ by the reaction of silver(I) fluoride with benzeneselenenyl bromide in dichloromethane under ultrasound irradiation. Treatment of internal…
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