Blockade of voltage-sensitive sodium channels by NS-7, a novel neuroprotective compound, in the rat brain
- T. Shimidzu, Y. Itoh, K. Kimura
- Biology, ChemistryNaunyn-Schmiedeberg's Archives of Pharmacology
- 15 April 1997
The results suggest that the blockade of neurotoxin receptor site 2 of VSSC in the brain contributes to the neuroprotective action of NS-7.
Selective and non-selective inhibition by enkephalins and noradrenaline of nociceptive response of lamina V type neurons in the spinal dorsal horn of the rabbit
- M. Satoh, S. Kawajiri, Y. Ukai, Masaki Yamamoto
- BiologyBrain Research
- 16 November 1979
Cardiac electrophysiological actions of NS-21 and its active metabolite, RCC-36, compared with terodiline
- S. Hayashi, T. Natsukawa, C. Suma, Y. Ukai, Y. Yoshikuni, K. Kimura
- Biology, MedicineNaunyn-Schmiedeberg's Archives of Pharmacology
- 15 April 1997
NS-21 is a newly developed drug for the treatment of urinary frequency and urinary incontinence and it has pharmacological properties similar to those of terodiline, however, whether NS-21 and its active metabolite, RCC-36, have any proarrhythmic activity.
Inhibition of Depolarization‐Induced Nitric Oxide Synthase Activation by NS‐7, a Phenylpyrimidine Derivative, in Primary Neuronal Culture
- S. Tatsumi, Y. Itoh, K. Kimura
- Biology, ChemistryJournal of Neurochemistry
- 1 January 1998
The present findings suggest that this compound inhibits depolarization‐induced NOS activation by reducing Ca2+ influx through blockade of Na+ and Ca2- channels in primary neuronal culture.
Inhibition of Ischemia‐Induced Fodrin Breakdown by a Novel Phenylpyrimidine Derivative NS‐7: An Implication for Its Neuroprotective Action in Rats with Middle Cerebral Artery Occlusion
- Y. Takagaki, Y. Itoh, Y. Aoki, Y. Ukai, Y. Yoshikuni, K. Kimura
- Biology, ChemistryJournal of Neurochemistry
- 1 June 1997
It is suggested that inhibition of calpain activation is implicated in the neuroprotective action of NS‐7, which produced a concentration‐dependent inhibition of hypoxia/hypoglycemia‐induced fodrin breakdown.
Involvement of peroxynitrite and hydroxyradical generated from nitric oxide in hypoxia/reoxygenation injury in rat cerebrocortical slices
- M. Oka, M. Hirouchi, Y. Itoh, Y. Ukai
- Biology, ChemistryNeuropharmacology
- 1 June 2000
Blockade by NS‐7, a Neuroprotective Compound, of Both L‐Type and P/Q‐Type Ca2+ Channels Involving Depolarization‐Stimulated Nitric Oxide Synthase Activity in Primary Neuronal Culture
It is suggested that NS‐7 inhibits NOS activation in primary neuronal culture by reducing Ca2+ entry through L‐type and P/Q‐type Ca 2+ channels, in which the inhibition is largely dependent on Ca2- channel activity.
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