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Involvement of the bcl-2 gene in human follicular lymphoma.
Recombinant DNA probes were cloned for the areas flanking the breakpoint on chromosome 18 in cells from a patient with acute lymphocytic leukemia of the B-cell type; cells of this line carry theExpand
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Discovery of Atg5/Atg7-independent alternative macroautophagy
Macroautophagy is a process that leads to the bulk degradation of subcellular constituents by producing autophagosomes/autolysosomes. It is believed that Atg5 (ref. 4) and Atg7 (ref. 5) are essentialExpand
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Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation.
From an acute B-cell leukemia cell line, a DNA probe was obtained that was specific for chromosome 18 and flanked the heavy chain joining region of the immunoglobulin heavy chain locus on chromosomeExpand
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Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death
Bcl-2 is the best characterized inhibitor of apoptosis, although the molecular basis of this action is not fully understood. Using a protein interaction cloning procedure, we identified a human geneExpand
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Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma.
  • Y. Tsujimoto, C. Croce
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 July 1986
We have determined that the bcl-2 (B-cell leukemia/lymphoma 2) gene is transcribed into three overlapping mRNAs, and we have cloned bcl-2 cDNA sequences. Sequence analysis of the bcl-2 cDNA clonesExpand
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The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining.
In this study, the joining sequences between chromosomes 14 and 18 on the 14q+ chromosomes of a patient with pre-B-cell leukemia and four patients with follicular lymphoma carrying a t(14;18)Expand
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Mutation in ankyrin repeats of the mouse Notch2 gene induces early embryonic lethality.
Notch family genes encode transmembrane proteins involved in cell-fate determination. Using gene targeting procedures, we disrupted the mouse Notch2 gene by replacing all but one of the ankyrinExpand
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Molecular cloning of the chromosomal breakpoint of B-cell lymphomas and leukemias with the t(11;14) chromosome translocation.
The chromosomal breakpoint of chronic lymphocytic leukemia (CLL) cells of the B-cell type carrying the translocated long arms of chromosomes 11 and 14 [t(11;14) (q13;q32)] was cloned. The breakpointExpand
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Multiple subcellular localization of bcl-2: detection in nuclear outer membrane, endoplasmic reticulum membrane, and mitochondrial membranes.
The use of biochemical fractionation, immunofluorescence laser-scanning confocal microscopy, and immunoelectron microscopy with mouse anti-human bcl-2 monoclonal antibody to analyze the subcellularExpand
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Clustering of breakpoints on chromosome 11 in human B-cell neoplasms with the t(11 ; 14) chromosome translocation
The t(11 ; 14) (ql3 ; q32) chromosome translocation has been reported in diffuse small and large cell lymphomas and in chronic lymphocytic leukaemia (B-CLL)1,2 and multiple myeloma3. BecauseExpand
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