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Establishment and characterisation of human carcinoembryonic antigen transgenic mice.
Interestingly, the expression of CEA protein in the transgenic mice was polarised to the luminal side of epithelial cells similar to the normal CEA expression in human tissues, andCEA expression was greatly reduced by the phosphatidylinositol-specific phospholipase C (PI-PLC) treatment. Expand
Expression of type‐IV collagenases in human tumor cell lines that can form liver colonies in chick embryos
Type‐IV collagenases expressed by tumor cells may play a role in facilitating colonization in chick embryos by inhibiting the activity of matrix metalloproteinases produced by tumor Cells. Expand
Tissue inhibitor of metalloproteinase 1 is a negative regulator of the metastatic ability of a human gastric cancer cell line, KKLS, in the chick embryo.
Data indicate that a reduced expression of TIMP-1 in KKLS cells is responsible for their consequent metastatic potential, and suggests that matrix metalloproteinase enzymatic activities are a prerequisite for metastatic activity in this experimental model system. Expand
Relationship between gallium 67 citrate scanning and transferrin receptor expression in lung diseases.
67Ga scan could be positive when cells have TFR and one should be able to observe cancer cells, clusters of alveolar macrophages, and epithelioid cells through the imaging of 67Ga scan in lung cancer and diffuse interstitial lung diseases. Expand
Expression of cell adhesion molecules in the lungs of patients with idiopathic pulmonary fibrosis.
It is suggested that E-selectin may play a role in the recruitment of neutrophils in regions of honeycombing in patients with IPF and that ICAM-1 may play an role in lymphocyte recruitment into the interstitium in addition to contributing to neutrophil recruitment within the airspaces of honeycomb regions. Expand
Nonspecific crossreacting antigen (NCA) is a major member of the carcinoembryonic antigen (CEA)-related gene family expressed in lung cancer.
It is suggested that NCA is a major member of the CEA-related gene family expressed in lung cancer, which is one of the most important tumour markers in the management of human carcinoma, including lung cancer. Expand
Identification of chemoresistant factors by protein expression analysis with iTRAQ for head and neck carcinoma
Proteins thought to mediate anticancer drug resistance using recent proteome technology are identified and α-enolase is identified as a true cisplatin chemoresistance factor and could be used as biomarkers for anticancer agent resistance and as targets of cancer therapy. Expand
Hypersensitivity pneumonitis in a soy sauce brewer caused by Aspergillus oryzae.
The first case of HP caused by A. otyzae is presented, which is presented as an occupational allergic disease among brewers exposed to A. oryzae by sprinkling A.oryzae on boiled soybeans. Expand
[A case of systemic primary amyloidosis with BHL and M-protein in pleural effusion].
A 76-year-old man admitted to the authors' hospital because of productive cough and dyspnea was diagnosed as systemic primary amyloidosis due to AL-protein, and the presence of M-protein in pleural effusion suggested that not only congestive heart failure due to cardiac amyloidsosis but also amyloidal deposition in the pleura would be related to the fluid production. Expand
Tissue Inhibitor of Metalloproteinase 1 Is a Negative Regulator of the Metastatic Ability of a Human Gastric Cancer Cell Line , KKLS , in the Chick Embryo 1
Tissue inhibitors of metalloproteinases (TIMPs) are the negative regu lators of matrix metalloproteinases that degrade extracellular matrix. We examined the regulatory role of 11MI'-I in theExpand