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An uncoupling agent containing strontium prevents bone loss by depressing bone resorption and maintaining bone formation in estrogen‐deficient rats
Trabecular bone loss in estrogen deficiency is associated with enhanced bone resorption with a smaller increase in bone formation. We previously reported that low doses of strontium can increaseExpand
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Tools in the Assessment of Sarcopenia
This review provides a framework for the development of an operational definition of sarcopenia and of the potential end points that might be adopted in clinical trials among older adults. While theExpand
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Incorporation and distribution of strontium in bone.
The distribution and incorporation of strontium into bone has been examined in rats, monkeys, and humans after oral administration of strontium (either strontium chloride or strontium ranelate).Expand
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In vitro effects of S12911-2 on osteoclast function and bone marrow macrophage differentiation.
In order to determine whether 5-[bis(carboxymethyl) amino]-2-carboxy4-cyano-3-thiopheneacetic acid distrontium salt (S12911-2) inhibits bone resorption by acting on the differentiation and/orExpand
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Health economics in the field of osteoarthritis: an expert's consensus paper from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO).
OBJECTIVES There is an important need to evaluate therapeutic approaches for osteoarthritis (OA) in terms of cost-effectiveness as well as efficacy. METHODS The ESCEO expert working group met toExpand
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Implications for Fracture Healing of Current and New Osteoporosis Treatments: An ESCEO Consensus Paper
Osteoporotic fracture healing is critical to clinical outcome in terms of functional recovery, morbidity, and quality of life. Osteoporosis treatments may affect bone repair, so insights into theirExpand
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Strontium distribution and interactions with bone mineral in monkey iliac bone after strontium salt (S 12911) administration
The analysis of the interaction of strontium (Sr) with bone mineral is of interest because a new agent containing Sr (S 12911) has shown positive effects on bone mass in various animal models ofExpand
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The divalent strontium salt S12911 enhances bone cell replication and bone formation in vitro.
In this study, we have determined the effect of the divalent strontium salt S12911 on bone cell replication and bone formation in two culture systems. In the first series of experiments,Expand
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Frailty and sarcopenia: definitions and outcome parameters
An operational definition of musculoskeletal decline in older people is needed to allow development of interventions for prevention or treatment, as was developed for the treatment of osteoporosis.Expand
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Quality of Life in Sarcopenia and Frailty
The reduced muscle mass and impaired muscle performance that define sarcopenia in older individuals are associated with increased risk of physical limitation and a variety of chronic diseases. TheyExpand
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