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An uncoupling agent containing strontium prevents bone loss by depressing bone resorption and maintaining bone formation in estrogen‐deficient rats
- P. Marie, M. Hott, Y. Tsouderos
- Biology, MedicineJournal of bone and mineral research : the…
- 1 May 1993
The data indicate that the divalent strontium salt S12911 is acting as an uncoupling agent that can prevent the femoral osteopenia and partially prevent the trabecular bone loss in E2‐deficient rats by inhibiting bone resorption without reducing bone formation.
Incorporation and distribution of strontium in bone.
Tools in the Assessment of Sarcopenia
It is proposed that sarcopenia may be optimally defined using a combination of measures of muscle mass and physical performance and co-primary outcomes, tailored to the specific intervention in question, may be the best way forward in this difficult but clinically important area.
Strontium distribution and interactions with bone mineral in monkey iliac bone after strontium salt (S 12911) administration
- G. Boivin, P. Deloffre, P. Meunier
- MedicineJournal of bone and mineral research : the…
- 1 September 1996
The analysis of the interaction of strontium (Sr) with bone mineral is of interest because a new agent containing Sr (S 12911) has shown positive effects on bone mass in various animal models of…
Health economics in the field of osteoarthritis: an expert's consensus paper from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO).
In vitro effects of S12911-2 on osteoclast function and bone marrow macrophage differentiation.
Implications for Fracture Healing of Current and New Osteoporosis Treatments: An ESCEO Consensus Paper
There is currently no evidence that osteoporosis treatments are detrimental for bone repair and some promising experimental evidence for positive effects on healing, notably for agents with a bone-forming mode of action, which may translate into therapeutic applications.
Efficacy and acceptability of intranasal 17 β-oestradiol for menopausal symptoms: randomised dose-response study
Frailty and sarcopenia: definitions and outcome parameters
Evidence is required for a link between improvements in the measures of muscle strength and/or physical activity and clinical outcomes to allow development of interventions to improve clinical outcomes in frail older patients.
Strontium Ranelate Increases Cartilage Matrix Formation
- Y. Henrotin, A. Labasse, J. Reginster
- BiologyJournal of bone and mineral research : the…
- 1 February 2001
Strontium ranelate strongly stimulates human cartilage matrix formation in vitro by a direct ionic effect without stimulating the chondroresorption processes, providing a preclinical basis for in vivo testing of strontium runelate in OA.