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Astrocytic-neuronal crosstalk: Implications for neuroprotection from brain injury
The older neurocentric view of the central nervous system (CNS) has changed radically with the growing understanding of the many essential functions of astrocytes. Advances in our understanding ofExpand
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Molecular mechanism underlying β1 regulation in voltage- and calcium-activated potassium (BK) channels
Significance β-Subunits (β1–β4) play a critical role in defining the properties of the voltage- and calcium-activated potassium (BK) channel, which in turn determines the physiological role that thisExpand
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A Marriage of Convenience: β-Subunits and Voltage-dependent K+ Channels*
The movement of ions across cell membranes is essential for a wide variety of fundamental physiological processes, including secretion, muscle contraction, and neuronal excitation. This movement isExpand
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Structural Determinants for Functional Coupling Between the β and α Subunits in the Ca2+-activated K+ (BK) Channel
High conductance, calcium- and voltage-activated potassium (BK, MaxiK) channels are widely expressed in mammals. In some tissues, the biophysical properties of BK channels are highly affected byExpand
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Intrinsic Electrostatic Potential in the BK Channel Pore: Role in Determining Single Channel Conductance and Block
The internal vestibule of large-conductance Ca2+ voltage-activated K+ (BK) channels contains a ring of eight negative charges not present in K+ channels of lower conductance (Glu386 and Glu389 inExpand
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Pharmacological consequences of the coexpression of BK channel α and auxiliary β subunits
Coded by a single gene (Slo1, KCM) and activated by depolarizing potentials and by a rise in intracellular Ca2+ concentration, the large conductance voltage- and Ca2+-activated K+ channel (BK) isExpand
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Changes in macrophage membrane properties during early Leishmania amazonensis infection differ from those observed during established infection and are partially explained by phagocytosis.
Understanding the impact of intracellular pathogens on the behavior of their host cells is key to designing new interventions. We are interested in how Leishmania alters the electrical function ofExpand
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The molecular nature of the 17β-Estradiol binding site in the voltage- and Ca2+-activated K+ (BK) channel β1 subunit
The accessory β1 subunit modulates the Ca2+- and voltage-activated K+ (BK) channel gating properties mainly by increasing its apparent Ca2+ sensitivity. β1 plays an important role in the modulationExpand
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17β-Estradiol Binds and Modulates BK Channel through its β1 Auxiliary Subunit
BK channels are ubiquitously expressed and are involved in the regulation of vascular smooth muscle contractility. Changes in the expression of the BK channel or its auxiliary β subunits areExpand
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