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How ERK1/2 activation controls cell proliferation and cell death: Is subcellular localization the answer?
Studies that further define the function of cytosolic ERK1/2 and its cytOSolic substrates that enhance cell death will be essential to harness this pathway for developing effective treatments for cancer and chronic inflammatory diseases.
Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction.
It is concluded that an autophagy-dependent pathway regulates cilia length during CS exposure and has potential as a therapeutic target for COPD.
Lung-Function Trajectories Leading to Chronic Obstructive Pulmonary Disease.
It is suggested that low FEV1 in early adulthood is important in the genesis of COPD and that accelerated decline inFEV1 is not an obligate feature of COPd.
CCN1 secretion and cleavage regulate the lung epithelial cell functions after cigarette smoke.
- H. Moon, Sang-Heon Kim, Yang Jin
- BiologyAmerican journal of physiology. Lung cellular and…
- 15 August 2014
It is hypothesized that cCCN1 promoted the epithelial cell death and tissue loss after prolonged CS exposure and was found in the bronchoalveolar lavage fluid from mice with emphysematous changes after 6 mo CS exposure.
Akt-mediated eminent expression of c-FLIP and Mcl-1 confers acquired resistance to TRAIL-induced cytotoxicity to lung cancer cells
Results identify c-FLIPL and Mcl-1L as the major determinants of acquired TRAIL resistance and could be molecular targets for improving the therapeutic value of TRAIL against lung cancer.
Protective role for club cell secretory protein-16 (CC16) in the development of COPD
- M. Laucho-Contreras, F. Polverino, C. Owen
- Biology, MedicineEuropean Respiratory Journal
- 19 February 2015
Airway CC16 expression was measured in COPD patients, smokers without COPD and non-smokers, and CC16 function in a cigarette smoke-induced COPD murine model found to contribute to the genesis of COPD.
Genotypes in matrix metalloproteinase 9 are a risk factor for COPD
- Y. Tesfaigzi, O. Myers, S. Belinsky
- Biology, PsychologyInternational journal of chronic obstructive…
- 1 September 2006
Variants of the MMP-9 gene are associated with COPD in this cohort of veterans and the haplotype analysis suggested that either 279Arg or a linked variant on this haplotype underlies the association.
Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis
In the combined meta-analysis, 22 loci associated at genome-wide significance are identified, including 13 new associations with COPD, including 12 associated with lung function in general population samples, while 4 are new.
Wood smoke exposure and gene promoter methylation are associated with increased risk for COPD in smokers.
- A. Sood, H. Petersen, Y. Tesfaigzi
- MedicineAmerican journal of respiratory and critical care…
- 1 November 2010
A novel link between wood smoke exposure and gene promoter methylation that synergistically increases the risk for reduced lung function in cigarette smokers is identified.
Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell type and phenotype associations
Genome-wide analysis of chronic obstructive pulmonary disease identifies 82 loci, 35 of which are new, and integrates gene expression and genomic annotation data shows enrichment of signals in lung tissue, smooth muscle and several lung cell types.