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N-substituted oxopyrimidines and nucleosides: structure-activity relationship for hypnotic activity as central nervous system depressant.
N3-Benzyluridine (3-(phenylmethyl)-1-beta-D-ribofuranosyluracil) (1f) and its related compounds were synthesized and evaluated for hypnotic activity as central depressants. The primary structuralExpand
  • 23
N3-benzyluridine exerts hypnotic activity in mice.
N3-Benzyluridine (I), a derivative of uracil (II) or uridine (III), has hypnotic effect on mice. The hypnotic effect of I was effected by intracerebroventricular injection. The response wasExpand
  • 18
Synthesis and sedative-hypnotic effects of N3-allyl- and N1-allyl-5,6-substituted 2-thiouracil derivatives in mice.
Twenty four thiouracil derivatives, including N3-allyl- (19) and N1-allyl-2-thiouracil (20) were synthesized and their pharmacological effects [sedative-hypnotic activity (loss of righting reflex andExpand
  • 12
Hypnotic activity of N3-benzylthymidine on mice.
The pharmacological effect in mice of N3-benzylthymidine (N3-ByTd) was examined by two routes of administration; intravenous (i.v.) and intracerebroventricular (i.c.v.), and compared with the effectExpand
  • 8
Preparation and pharmacological evaluation of N3-substituted thymidine derivatives as central depressants.
Central depressant effects in mice of N3-substituted thymidines (Td) (1) were examined by intracerebroventricular (i.c.v.) injection. Nine derivatives including the methyl, ethyl, propyl, allyl,Expand
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Central nervous system depressant effects of N3-substituted derivatives of deoxyuridine in mice.
N3-Substituted derivatives of deoxyuridine (1) were synthesized and their pharmacological effects were evaluated by intracerebroventricular (i.c.v.) injection in mice. Eleven derivatives, includingExpand
  • 5
In vivo and in vitro metabolic studies of N3-benzyluridine which exhibits hypnotic activity in mice.
The metabolism of N3-benzyluridine (N3-ByUd), which possesses hypnotic activity, was studied in mice. The decrease in brain concentration of N3-ByUd was faster than that of uridine (Ud) afterExpand
  • 6
Central depressant activities of N3-allyluridine and N3-allylthymidine.
The pharmacological effects of N3-allyluridine (N3-AUd) and N3-allylthymidine (N3-ATd) on the central nervous system (CNS) were examined by intracerebroventricular (i.c.v.) administration in mice.Expand
  • 5
Formation of carbon monoxide during mouse hepatic microsomal oxidative metabolism of cannabidiol; identification and determination.
Carbon monoxide (CO) was generated in the process of hepatic microsomal oxidative metabolism of cannabidiol (CBD). After the generated CO was reduced to methane (CH4) with a methanizer, CH4 formedExpand
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