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N-substituted oxopyrimidines and nucleosides: structure-activity relationship for hypnotic activity as central nervous system depressant.
TLDR
The result clearly indicates that the benzyl group and beta-D-ribofuranosyl, at the N3 and N1 positions, respectively, are necessary for hypnotic activity. Expand
N3-benzyluridine exerts hypnotic activity in mice.
TLDR
N3-Benzyluridine (I), a derivative of uracil (II) or uridine (III), has hypnotic effect on mice and may be a sleep-promoting substance basically, as reported by Komoda et al. Expand
Synthesis and sedative-hypnotic effects of N3-allyl- and N1-allyl-5,6-substituted 2-thiouracil derivatives in mice.
TLDR
Results showed that these thiouracils possessed many different effects such as sedative-hypnotic, anticonvulsant and/or convulsant, and that N3-allyl-5-methyl-2-thiouracil (18) and N1-allyL-5,6-dimethyl-2 -thiourACil (24) had the most potent hypnotic activity and antagonistic effect against PB, respectively. Expand
Preparation and pharmacological evaluation of N3-substituted thymidine derivatives as central depressants.
TLDR
Thymidine derivatives have central depressant activity, and the benzyl derivatives but not alkyl derivatives possess a hypnotic activity, although the derivatives tested significantly prolonged the pentobarbital-induced sleeping time. Expand
Hypnotic activity of N3-benzylthymidine on mice.
TLDR
Results reveal that both N3-benzylpyrimidine nucleosides have more direct depressant effects on the central nervous system (CNS) than the parent compounds. Expand
Formation of carbon monoxide during mouse hepatic microsomal oxidative metabolism of cannabidiol; identification and determination.
TLDR
The resorcinol moiety of CBD is important for CO formation, and cannabidivarin and olivetol produced CO, although none of delta 9-tetrahydrocannabinol, cannabinol and d-limonene did. Expand
Central nervous system depressant effects of N3-substituted derivatives of deoxyuridine in mice.
TLDR
It is indicated that deoxyuridine derivatives have generally central depressant activity, and the benzyl and xylyl derivatives, but not alkyl derivative, possess hypnotic activity. Expand
In vivo and in vitro metabolic studies of N3-benzyluridine which exhibits hypnotic activity in mice.
TLDR
The results indicate that N3-ByUd itself, but not its metabolites, produced central nervous system (CNS) depressant activity. Expand
Central depressant activities of N3-allyluridine and N3-allylthymidine.
TLDR
Results show that both N3-allylated compounds have more directly depressant effects on the central nervous system (CNS) than the parent compounds. Expand
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