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Transforming growth factor-beta1 induces the differentiation of myogenic cells into fibrotic cells in injured skeletal muscle: a key event in muscle fibrogenesis.
Transforming growth factor-beta1 (TGF-beta1) is thought to play a crucial role in fibrotic diseases. This study demonstrates for the first time that TGF-beta1 stimulation can induce myoblasts (C2C12… Expand
NS-398, a cyclooxygenase-2-specific inhibitor, delays skeletal muscle healing by decreasing regeneration and promoting fibrosis.
- W. Shen, Y. Li, Y. Tang, J. Cummins, J. Huard
- Biology, Medicine
- The American journal of pathology
- 1 October 2005
Nonsteroidal anti-inflammatory drugs are often prescribed after muscle injury. However, the effect of nonsteroidal anti-inflammatory drugs on muscle healing remains primarily controversial. To… Expand
New Hepatitis E Virus Genotype in Camels, the Middle East
In a molecular epidemiology study of hepatitis E virus (HEV) in dromedaries in Dubai, United Arab Emirates, HEV was detected in fecal samples from 3 camels. Complete genome sequencing of 2 strains… Expand
Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension.
- T. Bertero, W. Oldham, +28 authors S. Chan
- The Journal of clinical investigation
- 1 September 2016
Dysregulation of vascular stiffness and cellular metabolism occurs early in pulmonary hypertension (PH). However, the mechanisms by which biophysical properties of the vascular extracellular matrix… Expand
Monoclonal Antibody Clearance
- A. Datta-Mannan, D. Witcher, Y. Tang, J. Watkins, Victor J Wroblewski
- Medicine, Chemistry
- Journal of Biological Chemistry
- 19 January 2007
The neonatal Fc receptor (FcRn) plays a critical role in regulating IgG homeostasis in vivo. There are mixed reports on whether modification of the interaction with FcRn can be used as an engineering… Expand
Ultra-potent antibodies against respiratory syncytial virus: effects of binding kinetics and binding valence on viral neutralization.
We describe here the selection of ultra-potent anti-respiratory syncytial virus (RSV) antibodies for preventing RSV infection. A large number of antibody variants derived from Synagis (palivizumab),… Expand
miR‐17‐5p Promotes migration of human hepatocellular carcinoma cells through the p38 mitogen‐activated protein kinase‐heat shock protein 27 pathway
miR‐17‐5p is overexpressed in hepatocellular carcinoma (HCC), but the specific regulatory mechanisms of miR‐17‐5p in HCC remain unknown. We investigated the molecular basis of miR‐17‐5p as an… Expand
Cellular Toxicity of TiO2 Nanoparticles in Anatase and Rutile Crystal Phase
- Chan Jin, Y. Tang, +5 authors Y. Yang
- Chemistry, Medicine
- Biological Trace Element Research
- 1 June 2011
Titanium dioxide nanoparticles are massively produced and widely used in daily life, which has posed potential risk to human health. However, the molecular mechanism of TiO2 nanoparticles (NPs) with… Expand
Decorin gene transfer promotes muscle cell differentiation and muscle regeneration.
- Y. Li, Juan Li, +6 authors J. Huard
- Chemistry, Medicine
- Molecular therapy : the journal of the American…
- 1 September 2007
We have shown that decorin, a small leucine-rich proteoglycan, can inhibit transforming growth factor (TGF)-beta1 to prevent fibrous scar formation and improve muscle healing after injury. In the… Expand
MPT64 Protein from Mycobacterium tuberculosis Inhibits Apoptosis of Macrophages through NF-kB-miRNA21-Bcl-2 Pathway
MPT64 is one of the secreted proteins from Mycobacterium tuberculosis. Little is known about its role in infection by Mycobacterium tuberculosis. In this study, we demonstrated that MPT64 could… Expand