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Bioactive compounds in functional buckwheat food
Abstract Buckwheat is an ancient dicotyledonous crop belonging to Polygonaceae family. It is cultivated and adapted to marginal lands with harsh environments. Buckwheat has been praised as one of theExpand
MTOR-independent, autophagic enhancer trehalose prolongs motor neuron survival and ameliorates the autophagic flux defect in a mouse model of amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder caused by selective motor neuron degeneration. Abnormal protein aggregation and impaired protein degradation pathwaysExpand
Efficacy of allogeneic mesenchymal stem cell transplantation in patients with drug-resistant polymyositis and dermatomyositis
Objective To assess the safety and clinical efficacy of allogeneic mesenchymal stem cell transplantation (MSCT) in a small-scale pilot study with 10 patients with drug-resistant polymyositis (PM) orExpand
Spinal toll like receptor 3 is involved in chronic pancreatitis-induced mechanical allodynia of rat
BackgroundMechanisms underlying pain in chronic pancreatitis (CP) are incompletely understood. Our previous data showed that astrocytes were actively involved. However, it was unclear how astrocyticExpand
Caveolin-1 is related to invasion, survival, and poor prognosis in hepatocellular cancer
Caveolin-1 is the principal components of caveolae membranes, implicated in oncogenesis and angiogenesis. Until now, its expression and functional significance in hepatocellular carcinoma (HCC) areExpand
Structure-Activity Relationship for Hydrophobic Salts as Viscosity-Lowering Excipients for Concentrated Solutions of Monoclonal Antibodies
ABSTRACTPurposeTo discover, elucidate the structure-activity relationship (SAR), and explore the mechanism of action of excipients able to drastically lower the viscosities of concentrated aqueousExpand
Characterization of novel cytochrome P450 2E1 knockout rat model generated by CRISPR/Cas9.
A bacterial CRISPR-associated protein-9 nuclease (CRISPR/Cas9) from Streptococcus pyogenes has generated considerable excitement as a new tool to edit the targeted genome. Cytochrome P450 (CYP) 2E1Expand
Early pathogenic event of Alzheimer’s disease documented in iPSCs from patients with PSEN1 mutations
Alzheimer's disease (AD) is the most common age-related dementia characterized by progressive neuronal loss. However, the molecular mechanisms for the neuronal loss is still debated. Here, we usedExpand
Targeting Keap1 by miR-626 protects retinal pigment epithelium cells from oxidative injury by activating Nrf2 signaling.
Activation of the NF-E2-related factor 2 (Nrf2) cascade can offer significant protection against oxidative stress in retinal pigment epithelium (RPE) cells. Here, we indentified a novel kelch-likeExpand
Higher specificity of the activity of low molecular weight fucoidan for thrombin-induced platelet aggregation.
Algal fucoidans possess a wide variety of biological activities, including anticoagulation and antithrombosis, making them potential candidates for clinical use. We assessed the antiaggregant,Expand
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