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Experimental cancer cachexia induced by transplantable colon 26 adenocarcinoma in mice.
The present study investigates a tumor model for cachectic mice. Among various murine transplantable tumors, used for assessing cytostatics, we identified colon 26 adenocarcinoma (colon 26) asExpand
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A new subtype of the metalloprotease toxin gene and the incidence of the three bft subtypes among Bacteroides fragilis isolates in Japan.
The bft gene encoding Bacteroides fragilis toxin (BFT) has been devided into two subtypes, bft-1 and bft-2. We found a novel subtype by sequencing a segment of the bft gene from 64 enterotoxigenic B.Expand
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Anti-inflammatory activity and conformational behavior of a branched (1→3)-β-d-glucan from an alkaline extract of dictyophora indusiata fisch
A (1→6)-branched (1→3)-β-d-glucan (T-5-N), isolated from a m sodium hydroxide extract of the fruit bodies of Dictyophora indusiata Fisch., markedly exhibited anti-inflammatory effects on bothExpand
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Anticachectic activity of 5'-deoxy-5-fluorouridine in a murine tumor cachexia model, colon 26 adenocarcinoma.
Murine colon 26 adenocarcinoma causes a progressive weight loss and physiological changes associated with cachexia when it grows to a certain size. By the use of this tumor model several types ofExpand
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Conjugal transfer of imipenem resistance in Bacteroides fragilis.
Transfer of imipenem resistance in Bacteroides fragilis was studied. Clinical isolate B. fragilis 10-73 was highly resistant to imipenem. Imipenem resistance was transferred from 10-73 to B. fragilisExpand
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Effect of ammonium ion, inorganic phosphate and amino acids on the biosynthesis of protylonolide, a precursor of tylosin aglycone.
The production of tylosin by Streptomyces fradiae KA-427 in a defined medium was inhibited by ammonium ions and by inorganic phosphate. The production of protylonolide, an early lactonic intermediateExpand
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Brasilicardin A, a new terpenoid antibiotic from pathogenic Nocardia brasiliensis: fermentation, isolation and biological activity.
A novel tricyclic diterpenoid antibiotic, brasilicardin A, was isolated from the culture broth of Nocardia brasiliensis IFM 0406. The antibiotic exhibited immunosuppressive activity in a mouse mixedExpand
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A MATE Family Multidrug Efflux Transporter Pumps out Fluoroquinolones in Bacteroides thetaiotaomicron
ABSTRACT We cloned a gene, bexA, that codes for a multidrug efflux transporter from the chromosomal DNA of Bacteroides thetaiotaomicron ATCC 29741 by using an Escherichia coli ΔacrAB ΔacrEF mutant asExpand
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Valine as a precursor of n-butyrate unit in the biosynthesis of macrolide aglycone.
Sir: The biosynthesis of macrolide antibiotics is inhibited by ammonium ions.1) Previous papersl~3) from this laboratory reported that when producing organisms were grown in the presence of ammoniumExpand
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Active Efflux of Norfloxacin byBacteroides fragilis
ABSTRACT Norfloxacin was actively pumped out by Bacteroides fragilis, which is intrinsically resistant to most fluoroquinolones. Reserpine moderately inhibited the efflux. A one-step spontaneousExpand
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