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Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta.
The kinesin superfamily motor protein KIF1B has been shown to transport mitochondria. Here, we describe an isoform of KIF1B, KIF1Bbeta, that is distinct from KIF1B in its cargo binding domain. KIF1BExpand
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Loss of a conserved 7‐methylguanosine modification in 16S rRNA confers low‐level streptomycin resistance in bacteria
Streptomycin has been an important drug for the treatment of tuberculosis since its discovery in 1944. But numerous strains of Mycobacterium tuberculosis, the bacterial pathogen that causesExpand
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Long XMM observation of the narrow-line Seyfert 1 galaxy IRAS 13224−3809: rapid variability, high spin and a soft lag
The narrow-line Seyfert 1 galaxy IRAS 13224−3809 has been observed with XMM-Newton for 500 ks. The source is rapidly variable on time-scales down to a few 100 s. The spectrum shows strong broad Fe −Expand
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Rare earth elements activate the secondary metabolite–biosynthetic gene clusters in Streptomyces coelicolor A3(2)
Genome sequencing projects have revealed many biosynthesis gene clusters for the production of as-yet unknown secondary metabolites, especially in actinomycetes. Here, we report that the rare earthExpand
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Antibiotic Overproduction by rpsL and rsmG Mutants of Various Actinomycetes
ABSTRACT Certain streptomycin resistance mutations (i.e., rpsL and rsmG) result in the overproduction of antibiotics in various actinomycetes. Moreover, rpsL rsmG double-mutant strains show a furtherExpand
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Activation and products of the cryptic secondary metabolite biosynthetic gene clusters by rifampin resistance (rpoB) mutations in actinomycetes.
A subset of rifampin resistance (rpoB) mutations result in the overproduction of antibiotics in various actinomycetes, including Streptomyces, Saccharopolyspora, and Amycolatopsis, with H437Y andExpand
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Activating the expression of bacterial cryptic genes by rpoB mutations in RNA polymerase or by rare earth elements
Since bacteria were found to contain genes encoding enzymes that synthesize a plethora of potential secondary metabolites, interest has grown in the activation of these cryptic pathways. HomologousExpand
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Lincomycin at Subinhibitory Concentrations Potentiates Secondary Metabolite Production by Streptomyces spp.
ABSTRACT Antibiotics have either bactericidal or bacteriostatic activity. However, they also induce considerable gene expression in bacteria when used at subinhibitory concentrations (below the MIC).Expand
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Activation of secondary metabolite–biosynthetic gene clusters by generating rsmG mutations in Streptomyces griseus
Unlike other Streptomyces spp., the streptomycin producer Streptomyces griseus IFO13189 shows emergence of a small fraction of rsmG and rpsL mutants among spontaneous low- or high-levelExpand
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Metabolic perturbation to enhance polyketide and nonribosomal peptide antibiotic production using triclosan and ribosome-targeting drugs
Although transcriptional activation of pathwayspecific positive regulatory genes and/or biosynthetic genes is primarily important for enhancing secondary metabolite production, reinforcement ofExpand
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