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Signal transduction, pharmacological properties, and expression patterns of two rat metabotropic glutamate receptors, mGluR3 and mGluR4
The metabotropic glutamate receptors are coupled to intracellular signal transduction via G-proteins and consist of a family of at least five different subtypes, termed mGluR1-mGluR5. We studied theExpand
Role of the large extracellular domain of metabotropic glutamate receptors in agonist selectivity determination.
TLDR
This investigation demonstrates that the extracellular domain of mGluR is critical in determining agonists selectivity and that the mode of determination of agonist selectivity ofmGLUR is different from that of other G protein-coupled receptors for small molecule transmitters. Expand
Agonist analysis of 2‐(carboxycyclopropyl)glycine isomers for cloned metabotropic glutamate receptor subtypes expressed in Chinese hamster ovary cells
TLDR
This investigation demonstrates not only the importance of a particular isomeric structure of CCGs in the interaction with the mGluRs but also a clear receptor subtype specificity for the CCG‐receptor interaction, and indicates that theCCG isomers would serve as useful agonists for investigation of functions of themGluR family. Expand