Y. Takusagawa

Publications13
h-index7
Citations247
Highly Influential Citations15
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Purification and Characterization of L-2,3-Butanediol Dehydrogenase of Brevibacterium saccharolyticum C-1012 Expressed in Escherichia coli
The L-2,3-butanediol dehydrogenase produced in E. coli JM109/pLBD2-CTC was purified by 5 steps. The molecular mass of this enzyme was estimated at 110 kDa and the subunit was mesured to be 30 kDa.… Expand
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Production of l‐2,3‐butanediol by a new pathway constructed in Escherichia coli
Aims:  A metabolic pathway for l‐2,3‐butanediol (BD) as the main product has not yet been found. To rectify this situation, we attempted to produce l‐BD from diacetyl (DA) by producing simultaneous… Expand
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Crystal structure of meso-2,3-butanediol dehydrogenase in a complex with NAD+ and inhibitor mercaptoethanol at 1.7 A resolution for understanding of chiral substrate recognition mechanisms.
The crystal structure of a ternary complex of meso-2,3-butanediol dehydrogenase with NAD+ and a competitive inhibitor, mercaptoethanol, has been determined at 1.7 A resolution by means of molecular… Expand
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Unilateral interhemispheric keyhole approach for anterior cerebral artery aneurysms.
A special midline interhemispheric keyhole approach to the anterior communicating artery aneurysms is described. A small trephine opening of 3 cm in diameter is used in most cases. The detailed… Expand
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Structural basis for chiral substrate recognition by two 2,3‐butanediol dehydrogenases
2,3‐Butanediol dehydrogenase (BDH) catalyzes the NAD‐dependent redox reaction between acetoin and 2,3‐butanediol. There are three types of homologous BDH, each stereospecific for both substrate and… Expand
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[Epidermoid presenting as trigeminal neuralgia. Clinical significance and surgical approach].
In the past 4 years, the authors operated on 120 cases of trigeminal neuralgia. It is noteworthy that among the series there were 13 cases (11 %) of cerebellopontine (CP) angle epidermoid. This… Expand
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Enzymic Synthesis of Leukotriene B4 in Guinea Pig Brain
Abstract: Leukotriene B4 [5(S), 12(R)‐dihydroxy‐6,14‐cis‐8,10‐trans‐eicosatetraenoic acid] was obtained from endogenous arachidonic acid when slices of the guinea pig brain cortex were incubated with… Expand
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Stereochemical applications of the expression of the L‐2,3‐butanediol dehydrogenase gene in Escherichia coli
S. UI, Y. TAKUSAGAWA, T. OHTSUKI, A. MIMURA, M. OHKUMA AND T. KUDO. 2001. The L‐2,3‐butanediol dehydrogenase (L‐BDH) gene of Brevibacterium saccharolyticum was strongly expressed in Escherichia coli… Expand
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[A case of synchronous double primary malignant neoplasms (malignant astrocytoma, and lung cancer) diagnosed by autopsy].
Discussed is a deceased patient, a 54-year-old male, who was admitted to hospital with the chief complaint of motor aphasia. Computed assisted tomography in the cranium showed a massive lesion in the… Expand
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[A case of asbestosis complicated with double cancer of the stomach and colon].
A case of a double cancer, a stomach and a colon cancer, in a 84-year-old man is reported. The patient had an occupational history of asbestos exposure while working at two shipyards. His chest X-ray… Expand
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