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The pharmacokinetics of morphine and its glucuronide conjugate in a rat model of streptozotocin‐induced diabetes and the expression of MRP2, MRP3 and UGT2B1 in the liver
Objectives The aim was to investigate the pharmacokinetics of morphine and its metabolite, morphine‐3‐glucuronide (M3G), in a rat model of streptozotocin (STZ)‐induced diabetes.
The disposition of pravastatin in a rat model of streptozotocin-induced diabetes and organic anion transporting polypeptide 2 and multidrug resistance-associated protein 2 expression in the liver.
TLDR
The plasma pravastatin concentration was lower in the diabetic rat because the transportation of pravastsatin into hepatocytes was promoted along with increased expression of OATP2 and the biliary excretion ratio of pavastatin was significantly lower.
Effects of fatty acids, fatty amines and propylene glycol on rat stratum corneum lipids and proteins in vitro measured by fourier transform infrared/attenuated total reflection (FT-IR/ATR)
Fourier transform infrared/attenuated total reflection (FT-IR/ATR) spectroscopy was used to examine the effect of fatty acids, fatty amines and propylene glycol (PG) on the molecular mobility of rat
Effects of insulin on CYP3A activity and nicardipine disposition in streptozotocin-induced diabetic rats.
OBJECTIVES The aim of the study was to clarify the effect of insulin treatment on drug metabolism and disposition. METHODS We investigated the mRNA expression and activity of cytochrome P450 (CYP)
Altered expression of MRP2, MRP3 and UGT2B1 in the liver affects the disposition of morphine and its glucuronide conjugate in a rat model of cholestasis
Objectives The aim was to investigate the disposition of morphine and morphine‐3‐glucuronide (M3G) in a rat model of cholestasis induced by bile duct ligation (BDL).
Behavior of propylene glycol (PG) in dermis after treatment of rat intact skin surface with fatty acids, fatty amines or azone dissolved in PG.
TLDR
Rat abdominal intact skin was treated with fatty acids, fatty amines, or Azone which were dissolved in propylene glycol and PG appearing in the rat dermis was studied, and results suggested that both the distribution volume of PG in the dermis and the time of the saturation varied depending on the enhancer.
Antitumor effects of a novel lipophilic platinum complex (SM-11355) against a slowly-growing rat hepatic tumor after intra-hepatic arterial administration.
TLDR
It is demonstrated that SM-11355/Lipiodol exerted antitumor activity at a dose that showed no hepatic toxicity in the rat model, but CDDP/Llipiodol did not.
Effects of insulin on CYP3A activity and nicardipine disposition in streptozotocin‐induced diabetic rats
TLDR
The aim of the study was to clarify the effect of insulin treatment on drug metabolism and disposition and to establish a smoking cessation strategy for patients with type 2 diabetes.
Pharmacodynamics of chlorzoxazone in rats.
TLDR
Pharmacological effect-time profiles of a centrally acting muscle relaxant, chlorzoxazone, were evaluated by both rotarod and crossed extensor reflex methods and the CER method proved to be of use for assessing the drug response based on the dose-independent kinetics with high sensitivity.
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