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Studies on the Mechanisms of Leukocyte Adhesion to Cellulose Acetate Beads: An In Vitro Model to Assess the Efficacy of Cellulose Acetate Carrier‐based Granulocyte and Monocyte Adsorptive Apheresis
- K. Hiraishi, Y. Takeda, M. Adachi
- Medicine, BiologyTherapeutic apheresis and dialysis : official…
- 1 June 2003
CA beads might be an appropriate biomaterial for inducing extracorporeal immunomodulation as a treatment for auto‐immune diseases which are associated with pathological leukocyte activity.
The mode of actions of the Adacolumn therapeutic leucocytapheresis in patients with inflammatory bowel disease: a concise review
The mode of actions of Adacolumn GMA appears to be more than adsorption of excess neutrophils and TNF‐producing CD14+CD16+ monocytes per se, and the impact of GMA on the immune system is potentially very interesting in the context of treating immune‐related diseases.
A novel glycosylphosphatidyl inositol-anchored protein on human leukocytes: a possible role for regulation of neutrophil adherence and migration.
The finding that both GPI-80 and Vanin-1 are 40% homologous with human biotinidase suggests the existence of a biotinidsase superfamily of molecules that may be involved in the regulation of leukocyte trafficking.
Adacolumn for selective leukocytapheresis as a non‐pharmacological treatment for patients with disorders of the immune system: An adjunct or an alternative to drug therapy?
Selective depletion of myeloid cells appears to induce anti‐inflammatory effects and represents a non‐pharmacological treatment for patients with active IBD and the treatment has a clear drug‐sparing role.
Rapid acceleration of neutrophil apoptosis by tumor necrosis factor-alpha.
- Y. Takeda, H. Watanabe, S. Yonehara, T. Yamashita, S. Saito, F. Sendo
- Biology, MedicineInternational immunology
- 1 June 1993
It is demonstrated that human necrosis factor-alpha, a potent neutrophil activator, induces rapid (within 3 h) apoptosis of these cells, suggesting that apoptosis acceleration may be involved in processes by which neutrophils are prevented from damaging tissues.
Circulating miR-223 in Oral Cancer: Its Potential as a Novel Diagnostic Biomarker and Therapeutic Target
It is suggested that circulating miR-223 may serve as a potential biomarker for diagnosis and that it may represent a novel therapeutic target for treatment of oral cancer.
Inhibition by dexamethasone of human neutrophil apoptosis in vitro.
It is suggested that inhibition of human neutrophil apoptosis by Dex is mediated through glucocorticoid-receptor-induced de novo synthesis of macromolecules and that the decrease in sensitivity to TNF-alpha-induced apoptosis cannot be ascribed to a down-modulation of TNF receptors on these cells.
In vivo regulation of rat neutrophil apoptosis occurring spontaneously or induced with TNF-alpha or cycloheximide.
- H. Tsuchida, Y. Takeda, H. Takei, H. Shinzawa, T. Takahashi, F. Sendo
- Biology, MedicineJournal of immunology
- 1 March 1995
TNF-alpha-induced apoptosis of normal or inflammatory PBN and bone marrow neutrophils was enhanced by treatment with low doses of cycloheximide that alone were barely able to induce neutrophil apoptosis; however, apoptosisOf PEN was not.
Cross‐linking of GPI‐80, a possible regulatory molecule of cell adhesion, induces up‐regulation of CD11b/CD18 expression on neutrophil surfaces and shedding of L‐selectin
Results suggest that GPI‐80 may be a regulator of β2 integrin in neutrophils and the cross‐linking enhanced fMLP‐induced human neutrophil adherence.