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Age and Hypertension Promote Endothelium‐Dependent Contractions to Acetylcholine in the Aorta of the Rat
This study was undertaken to compare age-related changes in endothelium-dependent vascular responses in both hypertensive and normotensive rats. Aorta from normotensive Wistar-Kyoto (WKY) rats andExpand
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Decreased endothelium-dependent hyperpolarization to acetylcholine in smooth muscle of the mesenteric artery of spontaneously hypertensive rats.
The endothelium-dependent vascular relaxation to acetylcholine (ACh) in spontaneously hypertensive rats (SHR) may be impaired because of an imbalance of endothelium-derived relaxing factor andExpand
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Ageing suppresses endothelium‐dependent relaxation and generates contraction mediated by the muscarinic receptors in vascular smooth muscle of normotensive Wistar‐Kyoto and spontaneously hypertensive
We evaluated the effects of ageing and hypertension on endothelium-dependent relaxation and contraction of vascular smooth muscles. Aortic rings with and without endothelium from normotensiveExpand
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Inhibitory effect of cilnidipine on pressor response to acute cold stress in spontaneously hypertensive rats.
We investigated the effect of cilnidipine on cardiovascular and neuroendocrine responses to acute cold stress in conscious and unrestrained or moderately restrained spontaneously hypertensive ratsExpand
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Age-related changes in endothelium-dependent hyperpolarization in the rat mesenteric artery.
This study was designed to determine the age-related changes in the endothelium-dependent hyperpolarization to acetylcholine (ACh) and its contribution to relaxation in the isolated mesenteric arteryExpand
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Inhibitory effect of cilnidipine on vascular sympathetic neurotransmission and subsequent vasoconstriction in spontaneously hypertensive rats.
We reported previously that cilnidipine inhibited increases in blood pressure and plasma norepinephrine (NE) level in response to cold stress in spontaneously hypertensive rats (SHRs). In the presentExpand
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Effects of carbenoxolone Na on acute and chronic gastric ulcer models in experimental animals
Effects of carbenoxolone Na on acute or chronic types of gastric lesions or ulcer models produced in rats, guinea pigs, or dogs were studied. Carbenoxolone Na, given either orally orExpand
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Brain renin angiotensin system contributes to the salt-induced enhancement of hypertension in SHR.
The study was performed to determine whether the brain renin angiotensin system may contribute to the acceleration in hypertension following long-term salt loading in spontaneously hypertensive ratsExpand
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Hypertension and ageing impair acetylcholine‐induced vasodilation in rats
Objective To investigate the influence of hypertension and ageing on the in vivo effect of acetylcholine on blood pressure and regional vascular conductance and the inhibitory effect ofExpand
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Adrenoceptors in SHR: alterations in binding characteristics and intracellular signal transduction pathways.
There is much data on altered adrenoceptor function in the heart, blood vessel and kidney from spontaneously hypertensive rats (SHR). The enhancement of vascular and renal alpha-adrenoceptorExpand
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