Y. Takano

Publications40
h-index15
Citations1,964
Highly Influential Citations90
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Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation
The composite structure of the mammalian skull, which forms predominantly via intramembranous ossification, requires precise pre- and post-natal growth regulation of individual calvarial elements.… Expand
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Aging changes mechanical loading thresholds for bone formation in rats
The effect of aging on the mechanical loading thresholds for osteogenesis was investigated in rats. We applied mechanical loads varying from 30 to 64 N to the tibiae of 43 19‐month‐old rats using a… Expand
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Mechanotransduction in bone: role of strain rate.
Bone tissue can detect and respond to its mechanical environment, but there is no consensus for how bone cells detect mechanical loads. Some think that cells sense tissue deformation (strain) and… Expand
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Increased bone formation in rat tibiae after a single short period of dynamic loading in vivo.
Based on our quantum concept for mechanically adaptive bone formation, we hypothesized that a single bout of loading would increase bone formation at the endosteal surface in rat tibiae, with a… Expand
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Nitric oxide inhibitor L-NAME suppresses mechanically induced bone formation in rats.
We hypothesized that nitric oxide may act as an intermediary in the transduction of mechanical loading of bone into a bone formation response. In the present study, 48 rats were divided into the… Expand
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Multinucleate osteoclasts in medaka as evidence of active bone remodeling.
Putative sites of bone resorption in the acellular bony skeleton of the medaka fish (Oryzias latipes) were investigated primarily by RNA in situ hybridization and histological analysis. Numerous… Expand
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Site-specific localization of two distinct phosphatases along the osteoblast plasma membrane: tissue non-specific alkaline phosphatase and plasma membrane calcium ATPase.
In osteoblasts, alkaline phosphatase has been reported to be restricted to the basolateral domains. In recent studies, we have demonstrated phosphatase activities different from those of tissue… Expand
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Effect of transketolase modifications on carbon flow to the purine-nucleotide pathway in Corynebacterium ammoniagenes
Abstract. Transketolase, one of the enzymes in the nonoxidative branch of the pentose phosphate pathway, operates to shuttle ribose 5-phosphate and glycolytic intermediates together with… Expand
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Nippon Telegraph and Telephone Privatization Study: Experience of Japan and Lessons for Developing Countries
The privatization (or partial privatization) of Nippon Telegraph & Telephone (NTT) stands as the single largest effort of its kind in history and for that reason alone merits careful attention. The… Expand
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A variant of the Ekman-Westborg–Julin trait. A case report and review of the literature ☆
Abstract In 1974, Ekman-Westborg and Julin reported a case which had macrodontia, multituberculism, central cusps, and pulp invagination in many permanent teeth. Occurrence of these findings in an… Expand
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