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Processing of epidermal glucosylceramides is required for optimal mammalian cutaneous permeability barrier function.
The interstices of the mammalian stratum corneum contain lipids in a system of continuous membrane bilayers critical for the epidermal permeability barrier. During the transition from inner to outerExpand
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Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein.
The von Hippel-Lindau tumor suppressor protein (pVHL) negatively regulates hypoxia-inducible mRNAs such as the mRNA encoding vascular endothelial growth factor (VEGF). This activity has been linkedExpand
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Abstract An enzyme which catalyzes the cleavage of l -rhamnulose i -phosphate has been purified about 15-fold from extracts of l -rhamnose-grown Escherichia coli . The products of the reaction wereExpand
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Permeability barrier requirements regulate epidermal beta-glucocerebrosidase.
The intercellular spaces of the outermost layers of the epidermis (stratum corneum, SC) of terrestrial mammals contain a mixture of lipids, enriched in ceramides that are critical for the epidermalExpand
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Specificity of radioprotective and cytotoxic effects of cysteamine in HeLa S3 cells: generation of peroxide as the mechanism of paradoxical toxicity.
Cysteamine at 0.5-5 mM effectively kills ${\rm HeLa}\ {\rm S}_{3}$ cells, while it is much less toxic in higher concentration (30 mM). The toxicity develops gradually with time as peroxide generatesExpand
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beta-Glucocerebrosidase activity in murine epidermis: characterization and localization in relation to differentiation.
The intercellular lipids of the stratum corneum, which are highly enriched in ceramides, are critical for the mammalian epidermal permeability barrier. During the terminal stages of epidermalExpand
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The effects of glycosaminoglycans on thrombopoietin-induced megakaryocytopoiesis.
BACKGROUND AND OBJECTIVES The extracellular matrix plays an essential role in normal hematopoiesis. Proteoglycans and glycosaminoglycans (GAG) are major components of the matrix. In this study, theExpand
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New mechanism for foam cell generation in atherosclerotic lesions.
Because of a close association between platelets and macrophages in early fatty streak lesions, the hypothesis was tested that platelets contribute to lesion progression by directly enhancingExpand
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Repair of ultraviolet-damaged DNA in Micrococcus lysodeikticus. II. In vivo investigation on endonuclease activity specific for ultraviolet-irradiated DNA.
Abstract 1. 1. An investigation was carried out to clarify the in vivo role of an endonuclease found in extracts of Micrococcus lysodeikticus, which induces single-strand breaks inExpand
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Radiation Sensitivity of Megakaryocyte Colony-Forming Cells in Human Placental and Umbilical Cord Blood
Abstract Kashiwakura, I., Kuwabara, M., Inanami, O., Murakami, M., Hayase, Y., Takahashi, T.A. and Takagi Y. Radiation Sensitivity of Megakaryocyte Colony-Forming Cells in Human Placental andExpand
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