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Specificity of radioprotective and cytotoxic effects of cysteamine in HeLa S3 cells: generation of peroxide as the mechanism of paradoxical toxicity.
TLDR
The results suggest that the paradoxical cell-killing action of cysteamine can be ascribed to the generation of the peroxide by the compound, and in higher concentrations, cysteamines protects the cells by decomposing the produced peroxide.
Radiation Sensitivity of Megakaryocyte Colony-Forming Cells in Human Placental and Umbilical Cord Blood
TLDR
The results showed that the immature CFU-Meg were more radiosensitive than the mature CF U-Meg and that the combination of cytokines, including thrombopoietin, interleukin-3 and stem cell factor, affected the radiation sensitivity of CFu-Meg to the same extent as with throm bopiietin alone or in combination with FLT3LG and/or interleukein-11.
The effects of glycosaminoglycans on thrombopoietin-induced megakaryocytopoiesis.
TLDR
DS acts on an immature population of CD34+ cells, stimulates the proliferation of CFU-Meg, and enhances the terminal maturation of megakaryocytes and thrombopoiesis, suggesting that DS has a wide spectrum of action in promoting megakARYocytopoiesi and throttle-promoting activity.
[Effects of glycosaminoglycans on the in vitro colony formation of CD34+ megakaryocytic progenitor cells in human placental/umbilical cord blood].
TLDR
It is suggested that HA-p and HS promote the proliferation of immature CB CD34+ CFU-Meg in the presence of TPO.
The active form of cytochrome P-450 from bovine adrenocortical mitochondria.
TLDR
Findings indicate that the active form of cy tochrome P-450 from adrenocortical mitochondria is that containing 16 subunits, i.e. the form in which the cytochrome is normally isolated from adrenal mitochondria.
20α-Hydroxysteroid Dehydrogenase of Porcine Testes PURIFICATION AND PROPERTIES
Abstract A soluble 20α-hydroxysteroid dehydrogenase was found in porcine testes. The enzyme content was roughly proportional to the wet weight of the gland, when glands weighing 160 to 440 g were
Cysteamine rapidly decreases mitotic cells in random culture of HeLa S-3 cells.
TLDR
Inhibition of mitosis became gradually irreversible when the treatment was extended over 60 min, but cytolysis occurred much more slowly.
Radiation protection of mice by mixtures of -mercaptoethylquanidine (MEG) and cysteamine (MEA).
The injection of β-mercaptoethylguanidine bromide hydrobromide (MEG) together with cysteamine hydrochloride (MEA) afforded better protection of mice against Xirradiation than the injection of either
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