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Neurotoxicity induces cleavage of p35 to p25 by calpain
TLDR
Observations indicate that cleavage of p35 to p25 by calpain may be involved in the pathogenesis of Alzheimer's disease.
The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation.
TLDR
It is shown that both cdk5 and p35 proteins are present in the growth cones of developing neurons, suggesting a function of cdk4 in neuronal differentiation and a critical role in neurite outgrowth during neuronal differentiation.
p35, the Neuronal-specific Activator of Cyclin-dependent Kinase 5 (Cdk5) Is Degraded by the Ubiquitin-Proteasome Pathway*
TLDR
It is demonstrated that the p35/Cdk5 kinase can be subject to rapid turnover in vivo and suggest that phosphorylation of p35 upon Cdk5 Kinase activation plays a autoregulatory role in p35 degradation mediated by ubiquitin-mediated proteolysis.
A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5,
TLDR
The identification of optimal peptide substrates of CDK5, casein kinases I and II, NIMA, calmodulin-dependent kinases, Erk1, and phosphorylase kinase makes it possible to predict the potential in vivo targets of these kinases.
The mouse and human genes encoding the recognition component of the N-end rule pathway.
TLDR
The cloning of Ubr1 makes possible the construction of UBR1-lacking mouse strains, a prerequisite for the functional understanding of the mammalian N-end rule pathway.
A Mouse Amidase Specific for N-terminal Asparagine
TLDR
The isolation and analysis of a mouse cDNA and the corresponding gene (termed Ntan1) that encode a 310-residue amidohydrolase specific for N-terminal asparagine are reported, verifying that NtN-amidase retains its asparagus selectivity in vivo and can implement the asparagin-specific subset of the N-end rule.
Ubiquitin conjugation by the N-end rule pathway and mRNAs for its components increase in muscles of diabetic rats.
TLDR
Results suggest that small increases in both E2(14k) and E3alpha in muscles of insulin-deficient animals together accelerate Ub conjugation and protein degradation by the N-end rule pathway, the same pathway activated in cancer cachexia, sepsis, and hyperthyroidism.
Hyperthermia enhances mapatumumab-induced apoptotic death through ubiquitin-mediated degradation of cellular FLIP(long) in human colon cancer cells
TLDR
Mild hyperthermia potently reduced cellular FLIP(long), (c-FLIPL), a major regulator of the death receptor (DR) pathway of apoptosis, thereby enhancing humanized anti-DR4 antibody mapatumumab (Mapa)-mediated mitochondria-independent apoptosis and supports the application ofhyperthermia combined with other regimens to treat colorectal hepatic metastases.
Callosal axon guidance defects in p35−/− mice
TLDR
The results suggest that defective axonal fasciculation and guidance may be primary responses to the loss of p35 in the cortex, and postulates a role for the p35/cdk5 kinase in molecular signaling pathways necessary for proper guidance of selective axons during embryonic development.
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