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Reversible blockage of neurite development and growth cone formation in neuronal cultures of a temperature-sensitive mutant of Drosophila
The results would lend strong support to the notion that membrane recycling is crucial in the regulation of neuronal membrane adhesion and growth cone activity and if the primary defect of the shits1 mutation indeed resides in a membrane recycling mechanism common to different cell types. Expand
Induction of Insulin-dependent Diabetes by Streptozotocin Inhibition by Estrogens and Potentiation by Androgens
The results show that, in both BALB/cBOM and C57BL/6 mice, exogenous estrogens can suppress the high susceptibility of males and, Conversely, the normally streptozotocin-resistant females become as highly susceptible as males after the administration of androgens. Expand
Radiation pneumotoxicity in rats: modification by inhibitors of angiotensin converting enzyme.
- W. Ward, A. Molteni, C. Ts'ao, Y. T. Kim, J. Hinz
- International journal of radiation oncology…
A novel application for ACE inhibitors in general, and for Captopril in particular, as modifiers of radiation pneumotoxicity are suggested. Expand
Reversible inhibition of endocytosis in cultured neurons from the Drosophila temperature-sensitive mutant shibirets1.
The results support the notion that membrane recycling plays a critical role in regulating neurite outgrowth and provide baseline information for further mutational analysis of the mechanism underlying the membrane cycling process in cultured neurons. Expand
Studies of transketolase abnormality in Alzheimer's disease.
- K. Sheu, D. Clarke, Y. T. Kim, J. Blass, B. Harding, J. DeCicco
- Psychology, Medicine
- Archives of neurology
- 1 August 1988
The partially purified transketolase from each of eight well-nourished patients with Alzheimer's disease contained significantly less heat-stable component with a significantly longer half-life of… Expand
Reduced Growth Cone Motility in Cultured Neurons fromDrosophila Memory Mutants with a Defective cAMP Cascade
It is found that growth cone exploratory movement was nearly arrested by both mutations, even though they change cAMP levels in opposite directions, indicating that dynamic control of growth cone motility in developing Drosophila neurons requires optimal cAMP Levels within an operational range. Expand
Pentoxifylline does not spare acute radiation reactions in rat lung and skin.
The data indicate that pentoxifylline, despite some promising pharmacological actions, has no beneficial effect on acute radiation reactions in rat lung and skin. Expand
Distinctions in growth cone morphology and motility between monopolar and multipolar neurons in Drosophila CNS cultures.
An initial characterization of growth cone morphology and behavior in dissociated larval central nervous system (CNS) cultures of Drosophila found that separate CNS regions yielded cultures of different major cell types with distinct neuritic patterns that could be correlated with the morphology and motility of the associated growth cones. Expand
Structure-function analysis of angiotensin-converting enzyme inhibitors as modifiers of radiation-induced pulmonary endothelial dysfunction in rats.
The ACE inhibitor CGS13945 modifies radiation-induced pulmonary endothelial dysfunction in rats, indicating that the presence of a thiol group is not essential for therapeutic efficacy in this class of compounds and suggesting that there are at least two components to their mechanism of therapeutic action in this model. Expand
Effect of subchronic administration of antioxidants against cigarette smoke exposure in rats
Results indicate that although cigarette smoking induces antioxidant enzymes in the lung as a self defense mechanism, it seems to be not sufficient to protect the pulmonary system, and that chronic antioxidant feeding could be effective to reduce pulmonary damage induced by free radicals. Expand