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Identification of the Binding Site on Cytochrome P450 2B4 for Cytochrome b 5 and Cytochrome P450 Reductase*
TLDR
These studies indicate that the binding sites for cy tochrome b 5 and cytochrome P450 reductase are, as predicted, located on the proximal surface of cytochromes P450 2B4 and are partially overlapping but not identical. Expand
Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors.
TLDR
A simple batchwise affinity chromatography approach using two purine derivatives facilitated isolation of a small set of highly purified kinases suggests that this could be a general method for identifying intracellular targets relevant to a particular class of ligands. Expand
Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors.
TLDR
2,6,9-Trisubstituted purines have various and potent biological activities, despite high concentrations of competing endogenous purine ligands in living cells. Expand
Synthesis and biological evaluation of myoseverin derivatives: microtubule assembly inhibitors.
TLDR
A variety of myoseverin derivatives were synthesized and screened for inhibition of spindle assembly in Xenopus egg extracts and for microtubule disassembly in vitro and selected compounds were tested against 60 cancer cell lines at the National Cancer Institute as possible anticancer drug candidates. Expand
A new alternative adsorbent for the removal of cationic dyes from aqueous solution
Abstract Adsorption of Malachite green (MG) and Methylene blue (MB) from aqueous solutions on low cost adsorbent prepared from Annona squmosa seed (CAS) is studied experimentally. Results obtainedExpand
Synthesis of all possible regioisomers of scyllo-inositol phosphate.
TLDR
The stereoinversion of myo-inositol into scyllo- inositol was accomplished by Mitsunobu reaction of the vicinal cis-diol. Expand
A cyclin-dependent kinase inhibitor inducing cancer cell differentiation: biochemical identification using Xenopus egg extracts.
TLDR
Results indicate that the compound preferentially targets the G2/M-phase transition in vivo. Expand
Discovery of estrogen sulfotransferase inhibitors from a purine library screen.
TLDR
This paper aims to demonstrate the efforts towards in-situ applicability of EMMARM, which aims to provide real-time information about the response of the immune system to EMTs to polymethine-based chemotherapy. Expand
Homology modeling, molecular dynamics simulations, and analysis of CYP119, a P450 enzyme from extreme acidothermophilic archaeon Sulfolobus solfataricus.
TLDR
The results obtained from these experimental studies shall provide further validation of the suggested origins of stability and the structure-function relationships derived from the model structures of this enzyme. Expand
Rapid kinetic measurements of 45Ca2+ mobilization reveal that Ins(2,4,5)P3 is a partial agonist at hepatic InsP3 receptors.
TLDR
Results indicate that Ins(2, 4,5)P3 is a partial agonist at hepatic Ins(1,4,5), which may account for the lower cooperativity in the responses it evokes, the slower inactivation of InsP3 receptors and the characteristic patterns of Ca2+ spiking it evoked in intact cells. Expand
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