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The analgesic mechanism of processed Aconiti tuber: the involvement of descending inhibitory system.
Both oral and intracisternal administration of mesaconitine which is one of the main potent alkaloids contained in TJ-3021 produced analgesic effect in non-RCS rats, while intraperitoneal administration of naloxone did not produce the effect.
Antinociceptive effect of Gosha-jinki-gan, a Kampo medicine, in streptozotocin-induced diabetic mice.
- Y. Suzuki, K. Goto, A. Ishige, Y. Komatsu, J. Kamei
- Biology, ChemistryJapanese journal of pharmacology
The results suggest that the increased antinociceptive effect of Gosha-jinki-gan in diabetic mice is partly derived from the action of processed Aconiti tuber and that it is based on stimulation of spinal kappa-opioid receptors via dynorphin release.
Anti-ulcer effects of antioxidants: effect of probucol.
Effect of Aging on the Incidence of Digoxin Toxicity
- T. Miura, R. Kojima, Y. Sugiura, M. Mizutani, F. Takatsu, Y. Suzuki
- MedicineThe Annals of pharmacotherapy
- 1 April 2000
It was shown that the concentration range of this overlapping range of SDCs tended to broaden and shift to lower concentrations with increasing age, raising the possibility that patients >71 years show clinical evidence of digoxin toxicity despite having S DCs within the recommended therapeutic range.
Functional role of charybdotoxin-sensitive K+ channels in the resting state of cerebral, coronary and mesenteric arteries of the dog.
- M. Asano, K. Masuzawa-Ito, K. Sugita
- Biology, MedicineThe Journal of pharmacology and experimental…
- 1 December 1993
To determine the possible role of Ca(++)-activated K+ (KCa) channels in the regulation of resting tone of arteries, the effects of agents that interact with these channels on tension and 86Rb efflux…
Effects of various calmodulin antagonists on contraction of rabbit aortic strips.
Each Calmodulin antagonist tested has a different spectrum of action and of these only W-7 has a specific interaction with calmodulin.
Role of nitric oxide in rat nephrotoxic nephritis: comparison between inducible and constitutive nitric oxide synthase.
- V. Bremer, A. Tojo, M. Omata
- Biology, MedicineJournal of the American Society of Nephrology…
- 1 November 1997
Nitric oxide (NO), generated by inducible NO synthase (iNOS) in migrating macrophages, is increased in glomerulonephritis. This study investigates the effect of NO inhibition on rat nephrotoxic…
Antinociceptive mechanism of the aconitine alkaloids mesaconitine and benzoylmesaconine.
The NRM appeared to be the most sensitive region among the three tested locations, and microinjection of MA and BM into nucleus reticularis paragigantocellularis, nucleus raphe magnus, and periaqueductal gray elicited a dose-dependent antinociceptive action.
Acetoside, a component of Stachys sieboldii MIQ, may be a promising antinephritic agent: effect of acteoside on crescentic-type anti-GBM nephritis in rats.
- K. Hayashi, T. Nagamatsu, M. Itô, T. Hattori, Y. Suzuki
- Biology, MedicineJapanese journal of pharmacology
The results suggest that ACT may be a useful medicine against rapidly progressive glomerulonephritis, which is characterized by severe glomerular lesions with diffuse crescents.
Preventive actions of N-(3-aminopropionyl)-L-histidinato zinc (Z-103) through increases in the activities of oxygen-derived free radical scavenging enzymes in the gastric mucosa on ethanol-induced…
- M. Itô, D. Shii, T. Segami, R. Kojima, Y. Suzuki
- Medicine, ChemistryJapanese journal of pharmacology
The results suggest that Z-103 may partly protect rat gastric mucosa against ethanol-induced damage by scavenging oxygen-derived free radicals via increases in the synthesis of SOD-like and GSH-px enzymes in the mucosa.